TY - JOUR
T1 - Membrane cholesterol, protein phosphorylation, and lipid rafts.
AU - Edidin, M.
PY - 2001/1/30
Y1 - 2001/1/30
N2 - The functions of cholesterol and membrane microdomains in transmembrane signaling remain controversial. Edidin discusses the questions surrounding lipid rafts, membrane microdomains that have been biochemically defined but are difficult to visualize in vivo. He also discusses whether experiments showing correlation of changes in plasma membrane cholesterol with differentiation and the formation of adherens junctions in endothelial cells are consistent with a model in which lipid rafts influence the regulation of these processes.
AB - The functions of cholesterol and membrane microdomains in transmembrane signaling remain controversial. Edidin discusses the questions surrounding lipid rafts, membrane microdomains that have been biochemically defined but are difficult to visualize in vivo. He also discusses whether experiments showing correlation of changes in plasma membrane cholesterol with differentiation and the formation of adherens junctions in endothelial cells are consistent with a model in which lipid rafts influence the regulation of these processes.
UR - http://www.scopus.com/inward/record.url?scp=0035970177&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035970177&partnerID=8YFLogxK
U2 - 10.1126/scisignal.672001pe1
DO - 10.1126/scisignal.672001pe1
M3 - Review article
C2 - 11752636
AN - SCOPUS:0035970177
SN - 1937-9145
VL - 2001
SP - PE1
JO - Science's STKE : signal transduction knowledge environment
JF - Science's STKE : signal transduction knowledge environment
IS - 67
ER -