Membrane Attack Complex of Complement in Leukocytoclastic Vasculitis of the Skin

Presence and Possible Pathogenetic Role

Bart W. Boom, Coby J. Out-Luiting, Wink M. Baldwin, Marie Louise Westedt, Mohamed R. Daha, Bert Jan Vermeer

Research output: Contribution to journalArticle

Abstract

The presence of the membrane attack complex of complement (MAC) was studied by a two-step immunofluorescence method in 15 patients with leukocytoclastic vasculitis of the skin, using an antibody against MAC neoantigen. Perivascular deposits of MAC were present in 13 specimens of lesional skin and only two specimens of clinically uninvolved skin, suggesting a possible pathogenetic role for MAC in the development of a skin lesion. Control studies were performed on the clinically normal skin of 15 individuals (11 patients with various nonbullous skin diseases and four healthy volunteers) and on skin lesions of seven patients with inflammatory skin diseases. In the clinically normal skin of only one patient, perivascular deposits of MAC were detected. This patient had rheumatoid arthritis and a cutaneous eruption due to the administration of aurothioglucose. We conclude that the activation of the terminal components of the complement system may play an important role in the formation of lesions in leukocytoclastic vasculitis of the skin, but is not an indispensable condition. (Arch Dermatol 1987;123:1192-1195).

Original languageEnglish (US)
Pages (from-to)1192-1195
Number of pages4
JournalArchives of Dermatology
Volume123
Issue number9
DOIs
StatePublished - 1987
Externally publishedYes

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Complement Membrane Attack Complex
Skin
Skin Diseases
Aurothioglucose
Erythema elevatum diutinum
Fluorescent Antibody Technique
Rheumatoid Arthritis
Healthy Volunteers

ASJC Scopus subject areas

  • Dermatology

Cite this

Membrane Attack Complex of Complement in Leukocytoclastic Vasculitis of the Skin : Presence and Possible Pathogenetic Role. / Boom, Bart W.; Out-Luiting, Coby J.; Baldwin, Wink M.; Westedt, Marie Louise; Daha, Mohamed R.; Vermeer, Bert Jan.

In: Archives of Dermatology, Vol. 123, No. 9, 1987, p. 1192-1195.

Research output: Contribution to journalArticle

Boom, Bart W. ; Out-Luiting, Coby J. ; Baldwin, Wink M. ; Westedt, Marie Louise ; Daha, Mohamed R. ; Vermeer, Bert Jan. / Membrane Attack Complex of Complement in Leukocytoclastic Vasculitis of the Skin : Presence and Possible Pathogenetic Role. In: Archives of Dermatology. 1987 ; Vol. 123, No. 9. pp. 1192-1195.
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abstract = "The presence of the membrane attack complex of complement (MAC) was studied by a two-step immunofluorescence method in 15 patients with leukocytoclastic vasculitis of the skin, using an antibody against MAC neoantigen. Perivascular deposits of MAC were present in 13 specimens of lesional skin and only two specimens of clinically uninvolved skin, suggesting a possible pathogenetic role for MAC in the development of a skin lesion. Control studies were performed on the clinically normal skin of 15 individuals (11 patients with various nonbullous skin diseases and four healthy volunteers) and on skin lesions of seven patients with inflammatory skin diseases. In the clinically normal skin of only one patient, perivascular deposits of MAC were detected. This patient had rheumatoid arthritis and a cutaneous eruption due to the administration of aurothioglucose. We conclude that the activation of the terminal components of the complement system may play an important role in the formation of lesions in leukocytoclastic vasculitis of the skin, but is not an indispensable condition. (Arch Dermatol 1987;123:1192-1195).",
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