Membrane-associated crystallization of calcium oxalate in vitro

Saeed R. Khan, Paula N. Shevock, Raymond L. Hackett

Research output: Contribution to journalArticle

Abstract

Incubation of proximal tubular brush border membrane in a metastable calcium oxalate solution of low supersaturation resulted in the equimolar depletion of calcium and oxalate and the formation of monoclinic calcium oxalate crystals. We propose that membrane fragments from sloughed epithelial cells of the nephron can similarly induce crystallization in urine that is metastable for calcium oxalate.

Original languageEnglish (US)
Pages (from-to)116-120
Number of pages5
JournalCalcified Tissue International
Volume46
Issue number2
DOIs
StatePublished - Feb 1990
Externally publishedYes

Keywords

  • Calcium oxalate
  • Cellular membranes
  • Crystal nucleation
  • Kidney stones
  • Nephrolithiasis
  • Urolithiasis

ASJC Scopus subject areas

  • Endocrinology

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