Membrane-associated crystallization of calcium oxalate in vitro

Saeed R. Khan; Paula N. Shevock; Raymond L. Hackett

doi:10.1007/BF02556095

Membrane-associated crystallization of calcium oxalate in vitro

Saeed R. Khan, Paula N. Shevock, Raymond L. Hackett

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Incubation of proximal tubular brush border membrane in a metastable calcium oxalate solution of low supersaturation resulted in the equimolar depletion of calcium and oxalate and the formation of monoclinic calcium oxalate crystals. We propose that membrane fragments from sloughed epithelial cells of the nephron can similarly induce crystallization in urine that is metastable for calcium oxalate.

Original language	English (US)
Pages (from-to)	116-120
Number of pages	5
Journal	Calcified Tissue International
Volume	46
Issue number	2
DOIs	https://doi.org/10.1007/BF02556095
State	Published - Feb 1990
Externally published	Yes

Keywords

Calcium oxalate
Cellular membranes
Crystal nucleation
Kidney stones
Nephrolithiasis
Urolithiasis

ASJC Scopus subject areas

Endocrinology

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10.1007/BF02556095

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title = "Membrane-associated crystallization of calcium oxalate in vitro",

abstract = "Incubation of proximal tubular brush border membrane in a metastable calcium oxalate solution of low supersaturation resulted in the equimolar depletion of calcium and oxalate and the formation of monoclinic calcium oxalate crystals. We propose that membrane fragments from sloughed epithelial cells of the nephron can similarly induce crystallization in urine that is metastable for calcium oxalate.",

keywords = "Calcium oxalate, Cellular membranes, Crystal nucleation, Kidney stones, Nephrolithiasis, Urolithiasis",

author = "Khan, {Saeed R.} and Shevock, {Paula N.} and Hackett, {Raymond L.}",

year = "1990",

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AU - Khan, Saeed R.

AU - Shevock, Paula N.

AU - Hackett, Raymond L.

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N2 - Incubation of proximal tubular brush border membrane in a metastable calcium oxalate solution of low supersaturation resulted in the equimolar depletion of calcium and oxalate and the formation of monoclinic calcium oxalate crystals. We propose that membrane fragments from sloughed epithelial cells of the nephron can similarly induce crystallization in urine that is metastable for calcium oxalate.

AB - Incubation of proximal tubular brush border membrane in a metastable calcium oxalate solution of low supersaturation resulted in the equimolar depletion of calcium and oxalate and the formation of monoclinic calcium oxalate crystals. We propose that membrane fragments from sloughed epithelial cells of the nephron can similarly induce crystallization in urine that is metastable for calcium oxalate.

KW - Calcium oxalate

KW - Cellular membranes

KW - Crystal nucleation

KW - Kidney stones

KW - Nephrolithiasis

KW - Urolithiasis

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ER -

Membrane-associated crystallization of calcium oxalate in vitro

Abstract

Keywords

ASJC Scopus subject areas

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