Melatonin as the Possible Link Between Age-Related Retinal Regeneration and the Disrupted Circadian Rhythm in Elderly

Nadezda A. Stepicheva, Joseph Weiss, Peng Shang, Meysam Yazdankhah, Sayan Ghosh, Imran A. Bhutto, Stacey Hose, J. Samuel Zigler, Debasish Sinha

Research output: Chapter in Book/Report/Conference proceedingChapter


The association between age-related macular degeneration (AMD) and biological rhythms has been insufficiently studied; however there are several reasons to believe that impairment in circadian rhythm may affect incidence and pathogenesis of AMD. The current understanding of AMD pathology is based on age-related, cumulative oxidative damage to the retinal pigmented epithelium (RPE) partially due to impaired clearance of phagocytosed photoreceptor outer segments. In higher vertebrates, phagocytosis of the outer segments is synchronized by circadian rhythms and occurs shortly after dawn, followed by lysosomal-mediated clearance. Aging has been shown to be associated with the changes in circadian rhythmicity of melatonin production, which can be a major factor contributing to the impaired balance between phagocytosis and clearance and increased levels of reactive oxygen species resulting in degenerative changes in the retina. This minireview summarizes studies linking AMD with melatonin production and discusses challenges and perspectives of this area of research.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
Number of pages5
StatePublished - Jan 1 2019
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Age-related diseases
  • Age-related macular degeneration
  • Autophagy
  • Circadian rhythm
  • Melatonin
  • Ocular clock
  • Oxidative stress
  • Retinal pigmented epithelium

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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