Melas syndrome masquerading as herpes simplex encephalitis

Donald R. Johns, Alan G. Stein, Robert Wityk

Research output: Contribution to journalArticle


Herpes simplex encephalitis (HSE) is commonly treated empirically with acyclovir without confirmatory brain biopsy. Three consecutive adults with molecularly verified mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome presented with, and were treated for, apparent HSE. MELAS syndrome in adults may present as an atypical, recurrent form of HSE and should be added to the list of neurologic diseases that can mimic HSE.

Original languageEnglish (US)
Pages (from-to)2471-2473
Number of pages3
Issue number12
StatePublished - Dec 1993

ASJC Scopus subject areas

  • Clinical Neurology

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    Johns, D. R., Stein, A. G., & Wityk, R. (1993). Melas syndrome masquerading as herpes simplex encephalitis. Neurology, 43(12), 2471-2473.