Mel-CAM (CD146) expression in parotid mucoepidermoid carcinoma

Fábio Ramôa Pires, Ie Ming Shih, Danyel Elias Da Cruz Perez, Oslei Paes De Almeida, Luiz Paulo Kowalski

Research output: Contribution to journalArticle

Abstract

Mel-CAM (CD146) is a cell-cell adhesion protein found in normal and tumoral tissues. The aim of this study was to analyse Mel-CAM expression in mucoepidermoid carcinoma (MEC), and assess its importance in prognosis and its utility in differentiating high-grade MEC from squamous cell carcinoma (SCC). Immunohistochemical expression of Mel-CAM in 41 parotid MEC was correlated with clinical parameters. Ten cases of oral cavity SCC were included for comparison. Mel-CAM expression was found in 92.7% of the MEC but was not expressed by the SCC. Mel-CAM expression was greater in intermediate/high grade tumors, was weaker in patients that presented local recurrence, regional and distant metastasis, but no correlation between Mel-CAM and clinical stage and survival of the patients was found. Decreased Mel-CAM expression can impair cellular contact properties, facilitating growth, cell spreading and metastasis in MEC. Mel-CAM can also be useful in differentiating high grade MEC from SCC.

Original languageEnglish (US)
Pages (from-to)277-281
Number of pages5
JournalOral Oncology
Volume39
Issue number3
DOIs
StatePublished - Apr 2003

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Mucoepidermoid Carcinoma
Squamous Cell Carcinoma
Neoplasm Metastasis
Cell Adhesion
Mouth
Recurrence
Survival
Growth
Neoplasms

Keywords

  • CD146
  • Mel-CAM
  • Mucoepidermoid carcinoma
  • Parotid
  • Salivary glands
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Oncology

Cite this

Pires, F. R., Shih, I. M., Da Cruz Perez, D. E., De Almeida, O. P., & Kowalski, L. P. (2003). Mel-CAM (CD146) expression in parotid mucoepidermoid carcinoma. Oral Oncology, 39(3), 277-281. https://doi.org/10.1016/S1368-8375(02)00115-X

Mel-CAM (CD146) expression in parotid mucoepidermoid carcinoma. / Pires, Fábio Ramôa; Shih, Ie Ming; Da Cruz Perez, Danyel Elias; De Almeida, Oslei Paes; Kowalski, Luiz Paulo.

In: Oral Oncology, Vol. 39, No. 3, 04.2003, p. 277-281.

Research output: Contribution to journalArticle

Pires, FR, Shih, IM, Da Cruz Perez, DE, De Almeida, OP & Kowalski, LP 2003, 'Mel-CAM (CD146) expression in parotid mucoepidermoid carcinoma', Oral Oncology, vol. 39, no. 3, pp. 277-281. https://doi.org/10.1016/S1368-8375(02)00115-X
Pires, Fábio Ramôa ; Shih, Ie Ming ; Da Cruz Perez, Danyel Elias ; De Almeida, Oslei Paes ; Kowalski, Luiz Paulo. / Mel-CAM (CD146) expression in parotid mucoepidermoid carcinoma. In: Oral Oncology. 2003 ; Vol. 39, No. 3. pp. 277-281.
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