Megestrol acetate v tamoxifen in advanced breast cancer: Correlation of hormone receptors and response

D. S. Ettinger, J. Allegra, J. R. Bertino, P. Bonomi, H. Browder, P. Byrne, J. Carpenter, R. Catalano, R. Creech, B. Dana, H. Durivage, L. Einhorn, F. A. Greco, E. Greenwald, I. Henderson, F. Holmes, J. Keller, B. Kinzbrunner, M. Losada, S. LuedkeH. Muss, N. Nimeh, G. Wampler, N. Weinreb, J. Weisberg, R. Wheeler, P. H. Wiernik

Research output: Contribution to journalArticle

Abstract

This report describes the preliminary results from a randomized study comparing megestrol acetate with tamoxifen in the treatment of postmenopausal women with advanced breast cancer, correlating estrogen receptors (ER) and progesterone receptor (PgR) status with response. Patients received megestrol acetate (40 mg) orally four times daily or tamoxifen (10 mg) orally twice daily. If the initial therapy failed, patients were crossed over to the alternate treatment. Of 197 patients entered in the study, 190 were considered evaluable. The overall response rates were 35% with megestrol acetate and 42% with tamoxifen. Twenty-three percent ( 7 30) of patients responded to megestrol acetate after being crossed over from tamoxifen, while 22% ( 6 27) responded to tamoxifen after being crossed over from megestrol acetate. Response did not correlate significantly with combined receptor (ie, ER plus PgR) levels. A significant trend was seen between ER level and response only in the tamoxifen group. There was no association between PgR levels and response for either tamoxifen or megestrol acetate.

Original languageEnglish (US)
Pages (from-to)9-14
Number of pages6
JournalSeminars in oncology
Volume13
Issue number4 SUPPL. 4
StatePublished - Dec 1986
Externally publishedYes

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ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

Ettinger, D. S., Allegra, J., Bertino, J. R., Bonomi, P., Browder, H., Byrne, P., Carpenter, J., Catalano, R., Creech, R., Dana, B., Durivage, H., Einhorn, L., Greco, F. A., Greenwald, E., Henderson, I., Holmes, F., Keller, J., Kinzbrunner, B., Losada, M., ... Wiernik, P. H. (1986). Megestrol acetate v tamoxifen in advanced breast cancer: Correlation of hormone receptors and response. Seminars in oncology, 13(4 SUPPL. 4), 9-14.