Megestrol acetate for treatment of endometriosis

William D. Schlaff, Lorraine Dugoff, Marian D. Damewood, John A. Rock

Research output: Contribution to journalArticle


Between 1977–1989, 29 women with symptomatic endometriosis were treated with megestrol acetate by the Johns Hopkins Division of Reproductive Endocrinology. All had previously received one or more alternative medical treatments for endometriosis, in each case discontinued because of poor response or development of unacceptable side effects. Treatment consisted of a daily dose of 40 mg megestrol acetate orally for up to 24 months. Disease-related symptoms (dysmenorrhea, noncyclic pelvic pain, and dyspareunia) were relieved in 86% of the subjects treated with an adequate course of therapy. Side effects were fairly well tolerated, although eight women discontinued treatment within 2 months and two others stopped the drug by 4 months. These preliminary findings suggest that megestrol acetate may be an effective treatment for patients with endometriosis, even those who have been unresponsive to other modes of therapy.

Original languageEnglish (US)
Pages (from-to)646-648
Number of pages3
JournalObstetrics and gynecology
Issue number4
StatePublished - Apr 1990

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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    Schlaff, W. D., Dugoff, L., Damewood, M. D., & Rock, J. A. (1990). Megestrol acetate for treatment of endometriosis. Obstetrics and gynecology, 75(4), 646-648.