Meeting report: The role of the mobilome in cancer

Daniel Ardeljan, Martin S. Taylor, Kathleen Burns, Jef D. Boeke, Michael Graham Espey, Elisa C. Woodhouse, Thomas Kevin Howcroft

Research output: Contribution to journalArticle

Abstract

Approximately half of the human genome consists of repetitive sequence attributed to the activities of mobile DNAs, including DNA transposons, RNA transposons, and endogenous retro-viruses. Of these, only long interspersed elements (LINE-1 or L1) and sequences copied by LINE-1 remain mobile in our species today. Although cells restrict L1 activity by both transcriptional and posttranscriptional mechanisms, L1 derepression occurs in developmental and pathologic contexts, including many types of cancers. However, we have limited knowledge of the extent and consequences of L1 expression in premalignancies and cancer. Participants in this NIH strategic workshop considered key questions to enhance our understanding of mechanisms and roles the mobilome may play in cancer biology.

Original languageEnglish (US)
Pages (from-to)4316-4319
Number of pages4
JournalCancer Research
Volume76
Issue number15
DOIs
StatePublished - Aug 1 2016

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Long Interspersed Nucleotide Elements
Neoplasms
DNA Transposable Elements
Nucleic Acid Repetitive Sequences
Human Genome
RNA
Viruses
Education
DNA

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology
  • Cancer Research

Cite this

Ardeljan, D., Taylor, M. S., Burns, K., Boeke, J. D., Espey, M. G., Woodhouse, E. C., & Howcroft, T. K. (2016). Meeting report: The role of the mobilome in cancer. Cancer Research, 76(15), 4316-4319. https://doi.org/10.1158/0008-5472.CAN-15-3421

Meeting report : The role of the mobilome in cancer. / Ardeljan, Daniel; Taylor, Martin S.; Burns, Kathleen; Boeke, Jef D.; Espey, Michael Graham; Woodhouse, Elisa C.; Howcroft, Thomas Kevin.

In: Cancer Research, Vol. 76, No. 15, 01.08.2016, p. 4316-4319.

Research output: Contribution to journalArticle

Ardeljan, D, Taylor, MS, Burns, K, Boeke, JD, Espey, MG, Woodhouse, EC & Howcroft, TK 2016, 'Meeting report: The role of the mobilome in cancer', Cancer Research, vol. 76, no. 15, pp. 4316-4319. https://doi.org/10.1158/0008-5472.CAN-15-3421
Ardeljan D, Taylor MS, Burns K, Boeke JD, Espey MG, Woodhouse EC et al. Meeting report: The role of the mobilome in cancer. Cancer Research. 2016 Aug 1;76(15):4316-4319. https://doi.org/10.1158/0008-5472.CAN-15-3421
Ardeljan, Daniel ; Taylor, Martin S. ; Burns, Kathleen ; Boeke, Jef D. ; Espey, Michael Graham ; Woodhouse, Elisa C. ; Howcroft, Thomas Kevin. / Meeting report : The role of the mobilome in cancer. In: Cancer Research. 2016 ; Vol. 76, No. 15. pp. 4316-4319.
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