Meeting report: The role of the mobilome in cancer

Daniel Ardeljan, Martin S. Taylor, Kathleen H. Burns, Jef D. Boeke, Michael Graham Espey, Elisa C. Woodhouse, Thomas Kevin Howcroft

Research output: Contribution to journalArticlepeer-review

Abstract

Approximately half of the human genome consists of repetitive sequence attributed to the activities of mobile DNAs, including DNA transposons, RNA transposons, and endogenous retro-viruses. Of these, only long interspersed elements (LINE-1 or L1) and sequences copied by LINE-1 remain mobile in our species today. Although cells restrict L1 activity by both transcriptional and posttranscriptional mechanisms, L1 derepression occurs in developmental and pathologic contexts, including many types of cancers. However, we have limited knowledge of the extent and consequences of L1 expression in premalignancies and cancer. Participants in this NIH strategic workshop considered key questions to enhance our understanding of mechanisms and roles the mobilome may play in cancer biology.

Original languageEnglish (US)
Pages (from-to)4316-4319
Number of pages4
JournalCancer Research
Volume76
Issue number15
DOIs
StatePublished - Aug 1 2016

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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