Meeting report: Exploiting the tumor microenvironment for therapeutics

Giovanni Melillo, Gregg L Semenza

Research output: Contribution to journalArticle

Abstract

Recent progress in understanding the role of the tumor microenvironment in cancer progression was the subject of the 2nd International Tumor Metabolism Summit entitled "Exploiting the Tumor Microenvironment for Therapeutics," a meeting held at Palazzo Ducale in Genoa, Italy, October 7 to 8, 2005. One of the major conceptual advances in oncology over the last decade has been the appreciation that all major aspects of cancer biology are influenced by the tumor microenvironment. Two important means by which cancer cells adapt to their microenvironment are by reprogramming cellular glucose/energy metabolism to use pathways that generate ATP in the absence of O2 and by stimulating angiogenesis to increase O2 delivery. These responses are principally mediated at the transcriptional level by hypoxia-inducible factor-1. This meeting emphasized the complexity of the tumor microenvironment and opportunities for therapeutic intervention by targeting transcriptional and metabolic pathways that are activated during cancer progression. A better understanding of the crosstalk between signaling pathways and metabolic alterations that contribute to the cancer phenotype may provide insights leading to the development of novel therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)4558-4560
Number of pages3
JournalCancer Research
Volume66
Issue number9
DOIs
StatePublished - May 1 2006

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Tumor Microenvironment
Neoplasms
Metabolic Networks and Pathways
Therapeutics
Cellular Microenvironment
Hypoxia-Inducible Factor 1
Energy Metabolism
Italy
Adenosine Triphosphate
Phenotype
Glucose

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Meeting report : Exploiting the tumor microenvironment for therapeutics. / Melillo, Giovanni; Semenza, Gregg L.

In: Cancer Research, Vol. 66, No. 9, 01.05.2006, p. 4558-4560.

Research output: Contribution to journalArticle

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