Medulloblastoma: an analysis of time dose relationships and recurrence patterns

C. E. Smith, D. M. Long, T. K. Jones, S. H. Levitt

Research output: Contribution to journalArticle

Abstract

43 cases of medulloblastoma were retrospectively evaluated. Patients who initially received irradiation to the entire central nervous system had a better survival than those receiving limited irradiation. Patient survival was improved with a dose of 4500 to 5500 rads to the posterior fossa, 3500 rads to the remainder of the brain, and 3000 rads to the spinal cord. There was a 27% complication incidence in 11 patients who received supplemental intrathecal radiogold and their survival has not been significantly better than those who received only external beam therapy to the spinal cord. Reirradiation of intracranial recurrences improved survival, while reirradiation of spinal core recurrences did little to improve survival. Proven intracranial recurrences were all anterior to the posterior fossa. It is concluded that the entire brain should receive 5000 rads, the spine should receive 3500 rads, and recurrences should be accurately localized and retreated by irradiation.

Original languageEnglish (US)
Pages (from-to)722-728
Number of pages7
JournalCancer
Volume32
Issue number3
StatePublished - 1973
Externally publishedYes

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Medulloblastoma
Recurrence
Survival
Spinal Cord
Brain
Spine
Central Nervous System
Incidence

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Smith, C. E., Long, D. M., Jones, T. K., & Levitt, S. H. (1973). Medulloblastoma: an analysis of time dose relationships and recurrence patterns. Cancer, 32(3), 722-728.

Medulloblastoma : an analysis of time dose relationships and recurrence patterns. / Smith, C. E.; Long, D. M.; Jones, T. K.; Levitt, S. H.

In: Cancer, Vol. 32, No. 3, 1973, p. 722-728.

Research output: Contribution to journalArticle

Smith, CE, Long, DM, Jones, TK & Levitt, SH 1973, 'Medulloblastoma: an analysis of time dose relationships and recurrence patterns', Cancer, vol. 32, no. 3, pp. 722-728.
Smith CE, Long DM, Jones TK, Levitt SH. Medulloblastoma: an analysis of time dose relationships and recurrence patterns. Cancer. 1973;32(3):722-728.
Smith, C. E. ; Long, D. M. ; Jones, T. K. ; Levitt, S. H. / Medulloblastoma : an analysis of time dose relationships and recurrence patterns. In: Cancer. 1973 ; Vol. 32, No. 3. pp. 722-728.
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