Mediodorsal and visual thalamic connectivity differ in schizophrenia and bipolar disorder with and without psychosis history

Alan Anticevic, Genevieve Yang, Aleksandar Savic, John D. Murray, Michael W. Cole, Grega Repovs, Godfrey D. Pearlson, David C. Glahn

Research output: Contribution to journalArticle

Abstract

Empirical and theoretical studies implicate thalamocortical circuits in schizophrenia, supported by emerging resting-state functional connectivity studies (rs-fcMRI). Similar but attenuated alterations were found in bipolar disorder (BD). However, it remains unknown if segregated loops within thalamocortical systems show distinct rs-fcMRI alterations in schizophrenia. For instance, the mediodorsal (MD) nucleus, known to project to prefrontal networks, may be differently altered than the lateral geniculate nucleus (LGN), known to project to the occipital cortex. Also, it remains unknown if these circuits show different patterns of alterations in BD as a function of psychosis history, which may be associated with a more severe clinical course. We addressed these questions in 90 patients with chronic schizophrenia and 73 remitted BD patients (33 with psychosis history) matched to 146 healthy comparison subjects. We hypothesized that the MD vs LGN would show dissociations across diagnostic groups. We found that MD and LGN show more qualitative similarities than differences in their patterns of dysconnectivity in schizophrenia. In BD, patterns qualitatively diverged between thalamic nuclei although these effects were modest statistically. BD with psychosis history was associated with more severe dysconnectivity, particularly for the MD nucleus. Also, the MD nucleus showed connectivity reductions with the cerebellum in schizophrenia but not in BD. Results suggest dissociations for thalamic nuclei across diagnoses, albeit carefully controlling for medication is warranted in future studies. Collectively, these findings have implications for designing more precise neuroimaging-driven biomarkers that can identify common and divergent large-scale network perturbations across psychiatric diagnoses with shared symptoms.

Original languageEnglish (US)
Pages (from-to)1227-1243
Number of pages17
JournalSchizophrenia Bulletin
Volume40
Issue number6
DOIs
StatePublished - Nov 1 2014
Externally publishedYes

Fingerprint

Bipolar Disorder
Psychotic Disorders
Schizophrenia
Geniculate Bodies
Mediodorsal Thalamic Nucleus
Dissociative Disorders
Thalamic Nuclei
Occipital Lobe
Mental Disorders
Neuroimaging
Cerebellum
Healthy Volunteers
Theoretical Models
Biomarkers

Keywords

  • bipolar illness
  • connectivity
  • cross-diagnostic comparisons
  • mediodorsal nucleus
  • resting-state
  • schizophrenia
  • thalamus

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Anticevic, A., Yang, G., Savic, A., Murray, J. D., Cole, M. W., Repovs, G., ... Glahn, D. C. (2014). Mediodorsal and visual thalamic connectivity differ in schizophrenia and bipolar disorder with and without psychosis history. Schizophrenia Bulletin, 40(6), 1227-1243. https://doi.org/10.1093/schbul/sbu100

Mediodorsal and visual thalamic connectivity differ in schizophrenia and bipolar disorder with and without psychosis history. / Anticevic, Alan; Yang, Genevieve; Savic, Aleksandar; Murray, John D.; Cole, Michael W.; Repovs, Grega; Pearlson, Godfrey D.; Glahn, David C.

In: Schizophrenia Bulletin, Vol. 40, No. 6, 01.11.2014, p. 1227-1243.

Research output: Contribution to journalArticle

Anticevic, A, Yang, G, Savic, A, Murray, JD, Cole, MW, Repovs, G, Pearlson, GD & Glahn, DC 2014, 'Mediodorsal and visual thalamic connectivity differ in schizophrenia and bipolar disorder with and without psychosis history', Schizophrenia Bulletin, vol. 40, no. 6, pp. 1227-1243. https://doi.org/10.1093/schbul/sbu100
Anticevic, Alan ; Yang, Genevieve ; Savic, Aleksandar ; Murray, John D. ; Cole, Michael W. ; Repovs, Grega ; Pearlson, Godfrey D. ; Glahn, David C. / Mediodorsal and visual thalamic connectivity differ in schizophrenia and bipolar disorder with and without psychosis history. In: Schizophrenia Bulletin. 2014 ; Vol. 40, No. 6. pp. 1227-1243.
@article{064c371bf8ee4cf59e82c55ec7d3aa3b,
title = "Mediodorsal and visual thalamic connectivity differ in schizophrenia and bipolar disorder with and without psychosis history",
abstract = "Empirical and theoretical studies implicate thalamocortical circuits in schizophrenia, supported by emerging resting-state functional connectivity studies (rs-fcMRI). Similar but attenuated alterations were found in bipolar disorder (BD). However, it remains unknown if segregated loops within thalamocortical systems show distinct rs-fcMRI alterations in schizophrenia. For instance, the mediodorsal (MD) nucleus, known to project to prefrontal networks, may be differently altered than the lateral geniculate nucleus (LGN), known to project to the occipital cortex. Also, it remains unknown if these circuits show different patterns of alterations in BD as a function of psychosis history, which may be associated with a more severe clinical course. We addressed these questions in 90 patients with chronic schizophrenia and 73 remitted BD patients (33 with psychosis history) matched to 146 healthy comparison subjects. We hypothesized that the MD vs LGN would show dissociations across diagnostic groups. We found that MD and LGN show more qualitative similarities than differences in their patterns of dysconnectivity in schizophrenia. In BD, patterns qualitatively diverged between thalamic nuclei although these effects were modest statistically. BD with psychosis history was associated with more severe dysconnectivity, particularly for the MD nucleus. Also, the MD nucleus showed connectivity reductions with the cerebellum in schizophrenia but not in BD. Results suggest dissociations for thalamic nuclei across diagnoses, albeit carefully controlling for medication is warranted in future studies. Collectively, these findings have implications for designing more precise neuroimaging-driven biomarkers that can identify common and divergent large-scale network perturbations across psychiatric diagnoses with shared symptoms.",
keywords = "bipolar illness, connectivity, cross-diagnostic comparisons, mediodorsal nucleus, resting-state, schizophrenia, thalamus",
author = "Alan Anticevic and Genevieve Yang and Aleksandar Savic and Murray, {John D.} and Cole, {Michael W.} and Grega Repovs and Pearlson, {Godfrey D.} and Glahn, {David C.}",
year = "2014",
month = "11",
day = "1",
doi = "10.1093/schbul/sbu100",
language = "English (US)",
volume = "40",
pages = "1227--1243",
journal = "Schizophrenia Bulletin",
issn = "0586-7614",
publisher = "Oxford University Press",
number = "6",

}

TY - JOUR

T1 - Mediodorsal and visual thalamic connectivity differ in schizophrenia and bipolar disorder with and without psychosis history

AU - Anticevic, Alan

AU - Yang, Genevieve

AU - Savic, Aleksandar

AU - Murray, John D.

AU - Cole, Michael W.

AU - Repovs, Grega

AU - Pearlson, Godfrey D.

AU - Glahn, David C.

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Empirical and theoretical studies implicate thalamocortical circuits in schizophrenia, supported by emerging resting-state functional connectivity studies (rs-fcMRI). Similar but attenuated alterations were found in bipolar disorder (BD). However, it remains unknown if segregated loops within thalamocortical systems show distinct rs-fcMRI alterations in schizophrenia. For instance, the mediodorsal (MD) nucleus, known to project to prefrontal networks, may be differently altered than the lateral geniculate nucleus (LGN), known to project to the occipital cortex. Also, it remains unknown if these circuits show different patterns of alterations in BD as a function of psychosis history, which may be associated with a more severe clinical course. We addressed these questions in 90 patients with chronic schizophrenia and 73 remitted BD patients (33 with psychosis history) matched to 146 healthy comparison subjects. We hypothesized that the MD vs LGN would show dissociations across diagnostic groups. We found that MD and LGN show more qualitative similarities than differences in their patterns of dysconnectivity in schizophrenia. In BD, patterns qualitatively diverged between thalamic nuclei although these effects were modest statistically. BD with psychosis history was associated with more severe dysconnectivity, particularly for the MD nucleus. Also, the MD nucleus showed connectivity reductions with the cerebellum in schizophrenia but not in BD. Results suggest dissociations for thalamic nuclei across diagnoses, albeit carefully controlling for medication is warranted in future studies. Collectively, these findings have implications for designing more precise neuroimaging-driven biomarkers that can identify common and divergent large-scale network perturbations across psychiatric diagnoses with shared symptoms.

AB - Empirical and theoretical studies implicate thalamocortical circuits in schizophrenia, supported by emerging resting-state functional connectivity studies (rs-fcMRI). Similar but attenuated alterations were found in bipolar disorder (BD). However, it remains unknown if segregated loops within thalamocortical systems show distinct rs-fcMRI alterations in schizophrenia. For instance, the mediodorsal (MD) nucleus, known to project to prefrontal networks, may be differently altered than the lateral geniculate nucleus (LGN), known to project to the occipital cortex. Also, it remains unknown if these circuits show different patterns of alterations in BD as a function of psychosis history, which may be associated with a more severe clinical course. We addressed these questions in 90 patients with chronic schizophrenia and 73 remitted BD patients (33 with psychosis history) matched to 146 healthy comparison subjects. We hypothesized that the MD vs LGN would show dissociations across diagnostic groups. We found that MD and LGN show more qualitative similarities than differences in their patterns of dysconnectivity in schizophrenia. In BD, patterns qualitatively diverged between thalamic nuclei although these effects were modest statistically. BD with psychosis history was associated with more severe dysconnectivity, particularly for the MD nucleus. Also, the MD nucleus showed connectivity reductions with the cerebellum in schizophrenia but not in BD. Results suggest dissociations for thalamic nuclei across diagnoses, albeit carefully controlling for medication is warranted in future studies. Collectively, these findings have implications for designing more precise neuroimaging-driven biomarkers that can identify common and divergent large-scale network perturbations across psychiatric diagnoses with shared symptoms.

KW - bipolar illness

KW - connectivity

KW - cross-diagnostic comparisons

KW - mediodorsal nucleus

KW - resting-state

KW - schizophrenia

KW - thalamus

UR - http://www.scopus.com/inward/record.url?scp=84913531683&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84913531683&partnerID=8YFLogxK

U2 - 10.1093/schbul/sbu100

DO - 10.1093/schbul/sbu100

M3 - Article

VL - 40

SP - 1227

EP - 1243

JO - Schizophrenia Bulletin

JF - Schizophrenia Bulletin

SN - 0586-7614

IS - 6

ER -