Medication use, tamoxifen (TAM), and TAM metabolite concentrations in women with breast cancer

Lisa Gallicchio, Katherine Tkaczuk, Gwyn Lord, Malcolm Danton, Lynn M. Lewis, Chang K. Lim, Jodi A. Flaws

Research output: Contribution to journalArticle

Abstract

Tamoxifen (TAM) is commonly used as an adjuvant treatment for breast cancer. Although patients taking TAM are often taking medications for comorbidities, data regarding the interaction of TAM with other medications are limited. Thus, this study was carried out to determine whether medications co-prescribed with TAM significantly influence the plasma concentrations of TAM and its metabolites (N-desmethyltamoxifen; N-DMT and 4-hydroxytamoxifen; 4-OHT) in 98 women diagnosed with breast cancer. Participants taking diuretics had significantly higher plasma concentrations of TAM and N-DMT than participants not taking a diuretic. Arthritis/pain medication intake was negatively associated with plasma TAM concentrations. Chemotherapeutic agents, allergy drugs, anti-depressants, and diabetes medications did not significantly alter plasma TAM or metabolite concentrations. This suggests that diuretic or an arthritis/pain medication may affect TAM metabolism.

Original languageEnglish (US)
Pages (from-to)57-67
Number of pages11
JournalCancer Letters
Volume211
Issue number1
DOIs
StatePublished - Jul 28 2004
Externally publishedYes

Keywords

  • Breast cancer
  • Metabolism
  • Tamoxifen

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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  • Cite this

    Gallicchio, L., Tkaczuk, K., Lord, G., Danton, M., Lewis, L. M., Lim, C. K., & Flaws, J. A. (2004). Medication use, tamoxifen (TAM), and TAM metabolite concentrations in women with breast cancer. Cancer Letters, 211(1), 57-67. https://doi.org/10.1016/j.canlet.2004.04.001