Medical therapy of gonadotropin-producing and nonfunctioning pituitary adenomas

Mansur E. Shomali, Laurence Katznelson

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


Clinically nonfunctioning pituitary adenomas are one of the most common types of pituitary tumors. Unless they present with symptoms related to local mass effect, most tumors are detected incidentally when imaging studies are performed for other reasons. Although clinically nonfunctioning, most of these tumors have evidence, in vitro, of gonadotropin hormone or glycoprotein subunit production. The gonadotropins or their monomer submits rarely cause clinically identifiable effects. When these tumors present as macroadenomas, often with associated mass effect and hypopituitarism, primary therapy is neurosurgery. The role for medical therapy will be reviewed here.

Original languageEnglish (US)
Pages (from-to)89-98
Number of pages10
Issue number2
StatePublished - 2002
Externally publishedYes


  • Adenoma
  • Gonadotroph
  • Nonfunctioning
  • Pituitary
  • Tumors

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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