Abstract: This chapter is concerned with computer-integrated interventional medicine (CIIM). The fundamental premise of CIIM, which is sometimes also referred to as Computer-Integrated Surgery (CIS), is that the use of information and information-driven systems will fundamentally change clinical care by improving physicians' ability to plan, execute and follow up surgical and other interventional procedures. We first introduce the concepts of Surgical (or Interventional) CAD/CAM and Surgical Assistance. Next, we discuss the basic technology and techniques underlying these systems and provide examples of typical Surgical CAD/CAM and Surgical Assistant Systems. We conclude with a few thoughts about the growing significance and future prospects of the field.