Medical management of ischemic stuttering priapism: A contemporary review of the literature

Helen R. Levey, Omer Kutlu, Trinity Bivalacqua

Research output: Contribution to journalArticle

Abstract

Priapism is defined as a prolonged and persistent erection of the penis without sexual stimulation. This is a poorly understood disease process with little information on the pathophysiology of this erectile disorder. Complications from this disorder are devastating due to the irreversible erectile damage and resultant erectile dysfunction (ED). Stuttering priapism, though relatively rare, affects a high prevalence of men with sickle-cell disease (SCD) and presents a challenging problem with guidelines for treatment lacking or resulting in permanent ED. The mechanisms involved in the development of priapism in this cohort are poorly characterized; therefore, medical management of priapism represents a therapeutic challenge to urologists. Additional research is warranted, so we can effectively target treatments for these patients with prevention as the goal. This review gives an introduction to stuttering priapism and its clinical significance, specifically with regards to the patient with SCD. Additionally, the proposed mechanisms behind its pathophysiology and a summary of the current and future targets for medical management are discussed.

Original languageEnglish (US)
Pages (from-to)156-163
Number of pages8
JournalAsian Journal of Andrology
Volume14
Issue number1
DOIs
StatePublished - Jan 2012

Fingerprint

Priapism
Stuttering
Sickle Cell Anemia
Erectile Dysfunction
Penis
Therapeutics
Guidelines
Research

Keywords

  • erectile dysfunction
  • ischemic priapism
  • medical management
  • recurrent priapism
  • sickle cell disease
  • stuttering priapism
  • therapy
  • treatment

ASJC Scopus subject areas

  • Urology

Cite this

Medical management of ischemic stuttering priapism : A contemporary review of the literature. / Levey, Helen R.; Kutlu, Omer; Bivalacqua, Trinity.

In: Asian Journal of Andrology, Vol. 14, No. 1, 01.2012, p. 156-163.

Research output: Contribution to journalArticle

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