Mediation of separation distress by α2-adrenergic mechanisms in a non-human primate

James C. Harris; John D. Newman

doi:10.1016/0006-8993(87)90337-4

Mediation of separation distress by α₂-adrenergic mechanisms in a non-human primate

James C. Harris, John D. Newman

Kennedy Krieger Institute

Research output: Contribution to journal › Article › peer-review

Abstract

This study provides the first behavioral evidence in support of an α-adrenergic mechanism underlying imipramine's amelioration of separation distress. The rate of separation-induced vocalization by adult squirrel monkeys was decreased by imipramine and the α₂-adrenergic agonist clonidine, and increased by the α₂-adrenergic antagonist yohimbine. Yohimbine, but not the α₁-antagonist prazosin, reversed the clonidine effect suggesting that drugs acting directly on α₂-receptors may have a role in management of separation anxiety.

Original language	English (US)
Pages (from-to)	353-356
Number of pages	4
Journal	Brain research
Volume	410
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(87)90337-4
State	Published - May 5 1987

Keywords

Clonidine
Isolation call
Separation anxiety
Separation distress
Squirrel monkey
Yohimbine
α-Adrenergic receptor

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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