Abstract
This study provides the first behavioral evidence in support of an α-adrenergic mechanism underlying imipramine's amelioration of separation distress. The rate of separation-induced vocalization by adult squirrel monkeys was decreased by imipramine and the α2-adrenergic agonist clonidine, and increased by the α2-adrenergic antagonist yohimbine. Yohimbine, but not the α1-antagonist prazosin, reversed the clonidine effect suggesting that drugs acting directly on α2-receptors may have a role in management of separation anxiety.
Original language | English (US) |
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Pages (from-to) | 353-356 |
Number of pages | 4 |
Journal | Brain research |
Volume | 410 |
Issue number | 2 |
DOIs | |
State | Published - May 5 1987 |
Keywords
- Clonidine
- Isolation call
- Separation anxiety
- Separation distress
- Squirrel monkey
- Yohimbine
- α-Adrenergic receptor
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology