Mediation of augmented monocyte adhesiveness by thromboxane

Philip J. Spagnuolo, Jerrold J. Ellner, Aviv Hassid, Michael J. Dunn

Research output: Contribution to journalArticle

Abstract

We examined the potential contribution of thromboxanes in human monocyte adherence to plastic. Monocyte adherence to plastic could be augmented by various stimuli including lipopolysaccharide, chemotactic peptide, and supernates of antigen-stimulated lymphocytes. Increments in monocyte adhesiveness were suppressed by inhibition of cyclooxygenase, thromboxane synthetase, or by antiserum to thromboxane B2. Neither prostaglandin E2 or F significantly affected baseline or lipopolysaccharide-stimulated monocyte adherence. Additional experiments confirmed incremental production of thromboxane B2 by monocytes after incubation with lipopolysaccharide. Thromboxane B2 itself did not stimulate monocyte adhesiveness. These data demonstrate that monocytes release thromboxane A2 following stimulation and suggest that thromboxane A2 may play a significant role in monocyte-substrate attachment.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalInflammation
Volume12
Issue number1
DOIs
StatePublished - Feb 1988
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology
  • Cell Biology

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