TY - JOUR
T1 - Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons
AU - Riccio, Antonella
AU - Ahn, Sohyun
AU - Davenport, Christopher M.
AU - Blendy, Julie A.
AU - Ginty, David D.
PY - 1999/12/17
Y1 - 1999/12/17
N2 - Nerve growth factor (NGF) and other neurotrophins support survival of neurons through processes that are incompletely understood. The transcription factor CREB is a critical mediator of NGF-dependent gene expression, but whether CREB family transcription factors regulate expression of genes that contribute to NGF-dependent survival of sympathetic neurons is unknown, CREB- mediated gene expression was both necessary for NGF-dependent survival and sufficient on its own to promote survival of sympathetic neurons. Moreover, expression of Bcl-2 was activated by NGF and other neurotrophins by a CREB- dependent transcriptional mechanism. Overexpression of Bcl-2 reduced the death-promoting effects of CREB inhibition. Together, these data support a model in which neurotrophins promote survival of neurons, in part through a mechanism involving CREB family transcription factor-dependent expression of genes encoding prosurvival factors.
AB - Nerve growth factor (NGF) and other neurotrophins support survival of neurons through processes that are incompletely understood. The transcription factor CREB is a critical mediator of NGF-dependent gene expression, but whether CREB family transcription factors regulate expression of genes that contribute to NGF-dependent survival of sympathetic neurons is unknown, CREB- mediated gene expression was both necessary for NGF-dependent survival and sufficient on its own to promote survival of sympathetic neurons. Moreover, expression of Bcl-2 was activated by NGF and other neurotrophins by a CREB- dependent transcriptional mechanism. Overexpression of Bcl-2 reduced the death-promoting effects of CREB inhibition. Together, these data support a model in which neurotrophins promote survival of neurons, in part through a mechanism involving CREB family transcription factor-dependent expression of genes encoding prosurvival factors.
UR - http://www.scopus.com/inward/record.url?scp=0033579301&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033579301&partnerID=8YFLogxK
U2 - 10.1126/science.286.5448.2358
DO - 10.1126/science.286.5448.2358
M3 - Article
C2 - 10600750
AN - SCOPUS:0033579301
SN - 0036-8075
VL - 286
SP - 2358
EP - 2361
JO - Science
JF - Science
IS - 5448
ER -