Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons

Antonella Riccio, Sohyun Ahn, Christopher M. Davenport, Julie A. Blendy, David D. Ginty

Research output: Contribution to journalArticlepeer-review

Abstract

Nerve growth factor (NGF) and other neurotrophins support survival of neurons through processes that are incompletely understood. The transcription factor CREB is a critical mediator of NGF-dependent gene expression, but whether CREB family transcription factors regulate expression of genes that contribute to NGF-dependent survival of sympathetic neurons is unknown, CREB- mediated gene expression was both necessary for NGF-dependent survival and sufficient on its own to promote survival of sympathetic neurons. Moreover, expression of Bcl-2 was activated by NGF and other neurotrophins by a CREB- dependent transcriptional mechanism. Overexpression of Bcl-2 reduced the death-promoting effects of CREB inhibition. Together, these data support a model in which neurotrophins promote survival of neurons, in part through a mechanism involving CREB family transcription factor-dependent expression of genes encoding prosurvival factors.

Original languageEnglish (US)
Pages (from-to)2358-2361
Number of pages4
JournalScience
Volume286
Issue number5448
DOIs
StatePublished - Dec 17 1999

ASJC Scopus subject areas

  • General

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