Mechanochemical crosstalk during endocytic vesicle formation

Jian Liu, Yidi Sun, George F. Oster, David G. Drubin

Research output: Contribution to journalReview articlepeer-review


Membrane curvature has emerged as a key regulatory factor in endocytic vesicle formation. From a theoretical perspective, we summarize recent progress in understanding how membrane curvature and biochemical pathways are coupled and orchestrated during the coherent process of endocytic vesicle formation. We mainly focus on clathrin-mediated and actin-mediated endocytosis in yeast and in mammalian cells. We further speculate on how mechanochemical feedback could modulate other membrane-remodeling processes.

Original languageEnglish (US)
Pages (from-to)36-43
Number of pages8
JournalCurrent Opinion in Cell Biology
Issue number1
StatePublished - Feb 2010
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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