Mechano-electric interactions and their role in electrical function of the heart

J. Jeremy Rice; Peter Kohl

doi:10.1007/978-1-4471-4881-4_9

Mechano-electric interactions and their role in electrical function of the heart

J. Jeremy Rice, Peter Kohl

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The heart is an electrically controlled and chemically powered mechanical pump. There are complex interactions between cardiac structure and function, including electrophysiology, metabolism, and mechanics. These are based on a multitude of interdigitating regulatory loops with different inherent time-scales. This chapter will focus on the acute cross-talk between electrical and mechanical activity of the heart, and in particular its relevance for normal and abnormal heart rhythms.

Original language	English (US)
Title of host publication	Basic Foundations and Primary Electrical Diseases
Publisher	Springer-Verlag London Ltd
Pages	157-175
Number of pages	19
Volume	1
ISBN (Electronic)	9781447148814
ISBN (Print)	1447148800, 9781447148807
DOIs	https://doi.org/10.1007/978-1-4471-4881-4_9
State	Published - Mar 1 2013
Externally published	Yes

Keywords

Calcium handling
Cardiomyocyte
Excitation-contraction coupling
Heart
Mechano-electric coupling/mechano-electric feedback
Stretch
Stretch-activated channel

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1007/978-1-4471-4881-4_9

Cite this

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abstract = "The heart is an electrically controlled and chemically powered mechanical pump. There are complex interactions between cardiac structure and function, including electrophysiology, metabolism, and mechanics. These are based on a multitude of interdigitating regulatory loops with different inherent time-scales. This chapter will focus on the acute cross-talk between electrical and mechanical activity of the heart, and in particular its relevance for normal and abnormal heart rhythms.",

keywords = "Calcium handling, Cardiomyocyte, Excitation-contraction coupling, Heart, Mechano-electric coupling/mechano-electric feedback, Stretch, Stretch-activated channel",

author = "Rice, {J. Jeremy} and Peter Kohl",

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AU - Kohl, Peter

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AB - The heart is an electrically controlled and chemically powered mechanical pump. There are complex interactions between cardiac structure and function, including electrophysiology, metabolism, and mechanics. These are based on a multitude of interdigitating regulatory loops with different inherent time-scales. This chapter will focus on the acute cross-talk between electrical and mechanical activity of the heart, and in particular its relevance for normal and abnormal heart rhythms.

KW - Calcium handling

KW - Cardiomyocyte

KW - Excitation-contraction coupling

KW - Heart

KW - Mechano-electric coupling/mechano-electric feedback

KW - Stretch

KW - Stretch-activated channel

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EP - 175

BT - Basic Foundations and Primary Electrical Diseases

PB - Springer-Verlag London Ltd

ER -

Mechano-electric interactions and their role in electrical function of the heart

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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