TY - JOUR
T1 - Mechanistic and clinical insights at the scleroderma-cancer interface
AU - Shah, Ami A.
AU - Casciola-Rosen, Livia
N1 - Publisher Copyright:
© 2017 Wichtig International.
PY - 2017
Y1 - 2017
N2 - Emerging data suggest tantalizing links between cancer and systemic inflammatory rheumatic syndromes. In scleroderma, patients may have an increased risk of cancer, secondary to chronic inflammation and damage from the disease, malignant transformation promoted by immunosuppressive therapies, a shared susceptibility to both cancer and autoimmunity, or a common inciting exposure. However, it is increasingly recognized that a subset of patients develop cancer around the time that scleroderma clinically manifests, raising the question of cancer-induced autoimmunity. In this review, we discuss data suggesting a mechanistic link between cancer and the development of scleroderma, and the clinical implications of these findings.
AB - Emerging data suggest tantalizing links between cancer and systemic inflammatory rheumatic syndromes. In scleroderma, patients may have an increased risk of cancer, secondary to chronic inflammation and damage from the disease, malignant transformation promoted by immunosuppressive therapies, a shared susceptibility to both cancer and autoimmunity, or a common inciting exposure. However, it is increasingly recognized that a subset of patients develop cancer around the time that scleroderma clinically manifests, raising the question of cancer-induced autoimmunity. In this review, we discuss data suggesting a mechanistic link between cancer and the development of scleroderma, and the clinical implications of these findings.
KW - Autoantibodies
KW - Malignancy
KW - Systemic sclerosis
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U2 - 10.5301/jsrd.5000250
DO - 10.5301/jsrd.5000250
M3 - Review article
AN - SCOPUS:85052821541
SN - 2397-1983
VL - 2
SP - 153
EP - 159
JO - Journal of Scleroderma and Related Disorders
JF - Journal of Scleroderma and Related Disorders
IS - 3
ER -