Mechanisms underlying Myocarditis

Noel R. Rose, Daniela Čiháková, Jobert G. Barin

Research output: Contribution to journalReview articlepeer-review

Abstract

Myocarditis or its sequela, dilated cardiomyopathy, are important causes of heart failure. We have developed two experimental models in mice. Disease is induced in genetically susceptible mice by infection with cardiotropic Coxsackievirus B3, or by immunization with cardiac myosin. Two Th2 cytokines had opposite effects: IL-4 enhances disease whereas IL-13 reduces it. Th1 cytokines also exhibited opposing effects: IL-12 is pathogenic whereas IFNγ down-regulates disease.

Original languageEnglish (US)
Pages (from-to)207-212
Number of pages6
JournalDrug Discovery Today: Disease Mechanisms
Volume3
Issue number2
DOIs
StatePublished - 2006

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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