Mechanisms that regulate mechanosensory hair cell differentiation

U. Müller, A. Littlewood-Evans

Research output: Contribution to journalReview articlepeer-review

Abstract

Hair cells of the vertebrate inner ear are mechanosensors that detect sound, gravity and acceleration. They have a specialized cytoskeleton optimized for the transmission of mechanical force. Hair cell defects are a major cause of deafness. The cloning of disease genes and studies of model organisms have provided insights into the mechanisms that regulate the differentiation of hair cells and their cytoskeleton. The studies have also provided new insights into the function of receptors such as integrins and protocadherins, and cytoplasmic proteins such as Rho-type GTPases and unconventional myosins, in organizing the actin cytoskeleton.

Original languageEnglish (US)
Pages (from-to)334-342
Number of pages9
JournalTrends in Cell Biology
Volume11
Issue number8
DOIs
StatePublished - Aug 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology

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