Mechanisms that mediate stem cell self-renewal and differentiation

Haojian Zhang, Zack Z. Wang

Research output: Contribution to journalArticle

Abstract

Stem cells have two common properties: the capacity for self-renewal and the potential to differentiate into one or more specialized cell types. In general, stem cells can be divided into two broad categories: adult (somatic) stem cells and embryonic stem cells. Recent evidence suggested that tumors may contain "cancer stem cells" with indefinite potential for self-renewal. In this review, we will focus on the molecular mechanisms regulating embryonic stem cell self-renewal and differentiation, and discuss how these mechanisms may be relevant in cancer cells.

Original languageEnglish (US)
Pages (from-to)709-718
Number of pages10
JournalJournal of Cellular Biochemistry
Volume103
Issue number3
DOIs
StatePublished - Feb 15 2008
Externally publishedYes

Fingerprint

Embryonic Stem Cells
Stem cells
Stem Cells
Adult Stem Cells
Neoplastic Stem Cells
Neoplasms
Cell Self Renewal
Tumors
Cells

Keywords

  • Embryonic stem cells
  • Pluripotency
  • Self-renewal
  • Stem cells

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Mechanisms that mediate stem cell self-renewal and differentiation. / Zhang, Haojian; Wang, Zack Z.

In: Journal of Cellular Biochemistry, Vol. 103, No. 3, 15.02.2008, p. 709-718.

Research output: Contribution to journalArticle

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