Mechanisms of translational control in early development

Research output: Contribution to journalArticlepeer-review

Abstract

Oocytes accumulate a dowry of maternal mRNAs in preparation for embryogenesis. These maternal transcripts are kept dormant until late oogenesis or early embryogenesis when their translation is activated. In recent years, three types of translational control acting on maternal mRNAs have emerged: translational activation by cytoplasmic polyadenylation, translational activation by RNA localization, and regulated translational repression. In each case, translational control depends on the binding of trans-acting factors to sequences in the 3' untranslated region (3'UTR). Identification of these trans-acting factors is beginning to shed light on the molecular mechanisms that mediate translational control.

Original languageEnglish (US)
Pages (from-to)555-561
Number of pages7
JournalCurrent Opinion in Genetics and Development
Volume6
Issue number5
DOIs
StatePublished - Oct 1996

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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