Mechanisms of the Frank-Starling phenomena studied in intact hearts

D. Burkhoff; R. A. Stennett; K. Ogino; W. H. Barry; H. E D J Ter Keurs; E. Marban; G. Wier

Mechanisms of the Frank-Starling phenomena studied in intact hearts

D. Burkhoff, R. A. Stennett, K. Ogino, W. H. Barry, H. E D J Ter Keurs, E. Marban, G. Wier

Research output: Contribution to journal › Article › peer-review

Abstract

The impact of ventricular volume on the relationship between intracellular calcium and ventricular pressure under steady-state conditions was determined in intact ferret hearts. The results reveal major quantitative differences and minor qualitative differences between these relations and those previously measured in isolated intact and skinned cardiac muscle. The importance of these differences is discussed within the context of developing a comprehensive mechanistic theory to describe load-dependence of the intact ventricle.

Original language	English (US)
Pages (from-to)	155-161
Number of pages	7
Journal	Advances in Experimental Medicine and Biology
Volume	382
State	Published - 1995
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Cite this

@article{2e2a69fa1ac64b6c9a3fa43549ea2e56,

title = "Mechanisms of the Frank-Starling phenomena studied in intact hearts",

abstract = "The impact of ventricular volume on the relationship between intracellular calcium and ventricular pressure under steady-state conditions was determined in intact ferret hearts. The results reveal major quantitative differences and minor qualitative differences between these relations and those previously measured in isolated intact and skinned cardiac muscle. The importance of these differences is discussed within the context of developing a comprehensive mechanistic theory to describe load-dependence of the intact ventricle.",

author = "D. Burkhoff and Stennett, {R. A.} and K. Ogino and Barry, {W. H.} and {Ter Keurs}, {H. E D J} and E. Marban and G. Wier",

year = "1995",

language = "English (US)",

volume = "382",

pages = "155--161",

journal = "Advances in Experimental Medicine and Biology",

issn = "0065-2598",

publisher = "Springer New York",

}

TY - JOUR

T1 - Mechanisms of the Frank-Starling phenomena studied in intact hearts

AU - Burkhoff, D.

AU - Stennett, R. A.

AU - Ogino, K.

AU - Barry, W. H.

AU - Ter Keurs, H. E D J

AU - Marban, E.

AU - Wier, G.

PY - 1995

Y1 - 1995

N2 - The impact of ventricular volume on the relationship between intracellular calcium and ventricular pressure under steady-state conditions was determined in intact ferret hearts. The results reveal major quantitative differences and minor qualitative differences between these relations and those previously measured in isolated intact and skinned cardiac muscle. The importance of these differences is discussed within the context of developing a comprehensive mechanistic theory to describe load-dependence of the intact ventricle.

AB - The impact of ventricular volume on the relationship between intracellular calcium and ventricular pressure under steady-state conditions was determined in intact ferret hearts. The results reveal major quantitative differences and minor qualitative differences between these relations and those previously measured in isolated intact and skinned cardiac muscle. The importance of these differences is discussed within the context of developing a comprehensive mechanistic theory to describe load-dependence of the intact ventricle.

UR - http://www.scopus.com/inward/record.url?scp=0029126307&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029126307&partnerID=8YFLogxK

M3 - Article

C2 - 8540392

AN - SCOPUS:0029126307

SN - 0065-2598

VL - 382

SP - 155

EP - 161

JO - Advances in Experimental Medicine and Biology

JF - Advances in Experimental Medicine and Biology

ER -

Mechanisms of the Frank-Starling phenomena studied in intact hearts

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this