Mechanisms of the Frank-Starling phenomena studied in intact hearts

D. Burkhoff, R. A. Stennett, K. Ogino, W. H. Barry, H. E D J Ter Keurs, E. Marban, G. Wier

Research output: Contribution to journalArticlepeer-review


The impact of ventricular volume on the relationship between intracellular calcium and ventricular pressure under steady-state conditions was determined in intact ferret hearts. The results reveal major quantitative differences and minor qualitative differences between these relations and those previously measured in isolated intact and skinned cardiac muscle. The importance of these differences is discussed within the context of developing a comprehensive mechanistic theory to describe load-dependence of the intact ventricle.

Original languageEnglish (US)
Pages (from-to)155-161
Number of pages7
JournalAdvances in Experimental Medicine and Biology
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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