Mechanisms of regulated and dysregulated CARD11 signaling in adaptive immunity and disease

Jacquelyn R. Bedsaul; Nicole M. Carter; Katelynn E. Deibel; Shelby M. Hutcherson; Tyler A. Jones; Zhaoquan Wang; Chao Yang; Yong Kang Yang; Joel L. Pomerantz

doi:10.3389/fimmu.2018.02105

Mechanisms of regulated and dysregulated CARD11 signaling in adaptive immunity and disease

Jacquelyn R. Bedsaul, Nicole M. Carter, Katelynn E. Deibel, Shelby M. Hutcherson, Tyler A. Jones, Zhaoquan Wang, Chao Yang, Yong Kang Yang, Joel L. Pomerantz

School of Medicine

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

CARD11 functions as a key signaling scaffold that controls antigen-induced lymphocyte activation during the adaptive immune response. Somatic mutations in CARD11 are frequently found in Non-Hodgkin lymphoma, and at least three classes of germline CARD11 mutations have been described as the basis for primary immunodeficiency. In this review, we summarize our current understanding of how CARD11 signals, how its activity is regulated, and how mutations bypass normal regulation to cause disease.

Original language	English (US)
Article number	2105
Journal	Frontiers in immunology
Volume	9
Issue number	SEP
DOIs	https://doi.org/10.3389/fimmu.2018.02105
State	Published - Sep 19 2018

Keywords

B cell receptor
Bcl10
CARD11
Lymphoma
MALT1
Primary immunodeficiency
T cell receptor

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.3389/fimmu.2018.02105

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title = "Mechanisms of regulated and dysregulated CARD11 signaling in adaptive immunity and disease",

abstract = "CARD11 functions as a key signaling scaffold that controls antigen-induced lymphocyte activation during the adaptive immune response. Somatic mutations in CARD11 are frequently found in Non-Hodgkin lymphoma, and at least three classes of germline CARD11 mutations have been described as the basis for primary immunodeficiency. In this review, we summarize our current understanding of how CARD11 signals, how its activity is regulated, and how mutations bypass normal regulation to cause disease.",

keywords = "B cell receptor, Bcl10, CARD11, Lymphoma, MALT1, Primary immunodeficiency, T cell receptor",

author = "Bedsaul, {Jacquelyn R.} and Carter, {Nicole M.} and Deibel, {Katelynn E.} and Hutcherson, {Shelby M.} and Jones, {Tyler A.} and Zhaoquan Wang and Chao Yang and Yang, {Yong Kang} and Pomerantz, {Joel L.}",

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AU - Bedsaul, Jacquelyn R.

AU - Carter, Nicole M.

AU - Deibel, Katelynn E.

AU - Hutcherson, Shelby M.

AU - Jones, Tyler A.

AU - Wang, Zhaoquan

AU - Yang, Chao

AU - Yang, Yong Kang

AU - Pomerantz, Joel L.

PY - 2018/9/19

Y1 - 2018/9/19

N2 - CARD11 functions as a key signaling scaffold that controls antigen-induced lymphocyte activation during the adaptive immune response. Somatic mutations in CARD11 are frequently found in Non-Hodgkin lymphoma, and at least three classes of germline CARD11 mutations have been described as the basis for primary immunodeficiency. In this review, we summarize our current understanding of how CARD11 signals, how its activity is regulated, and how mutations bypass normal regulation to cause disease.

AB - CARD11 functions as a key signaling scaffold that controls antigen-induced lymphocyte activation during the adaptive immune response. Somatic mutations in CARD11 are frequently found in Non-Hodgkin lymphoma, and at least three classes of germline CARD11 mutations have been described as the basis for primary immunodeficiency. In this review, we summarize our current understanding of how CARD11 signals, how its activity is regulated, and how mutations bypass normal regulation to cause disease.

KW - B cell receptor

KW - Bcl10

KW - CARD11

KW - Lymphoma

KW - MALT1

KW - Primary immunodeficiency

KW - T cell receptor

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SN - 1664-3224

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JO - Frontiers in immunology

JF - Frontiers in immunology

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ER -

Mechanisms of regulated and dysregulated CARD11 signaling in adaptive immunity and disease

Abstract

Keywords

ASJC Scopus subject areas

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