Mechanisms of persistent NF-κB activation by HTLV-I tax

Edward W. Harhaj, Nicole S. Harhaj

Research output: Contribution to journalArticle

Abstract

Human T cell leukemia virus type I (HTLV-I) is the causative agent of a fatal malignancy known as adult T cell leukemia (ATL). The HTLV-I Tax protein is thought to play a significant role in the initiation and pathogenesis of HTLV-I-mediated disease. Tax is a potent oncogene that deregulates cellular gene expression by persistently activating signaling pathways such as NF-κB. Tax activation of NF-κB is critical for the immortalization and survival of HTLV-I-infected T cells. In this review, we describe recent insights into the mechanisms employed by Tax to activate the canonical and noncanonical NF-κB signaling pathways. The adaptor function of Tax appears to be a common and important mechanism for the pathological activation of both NF-κB pathways.

Original languageEnglish (US)
Pages (from-to)83-91
Number of pages9
JournalIUBMB Life
Volume57
Issue number2
DOIs
StatePublished - Feb 2005
Externally publishedYes

Fingerprint

Human T-lymphotropic virus 1
T-cells
Taxation
Viruses
Chemical activation
Adult T Cell Leukemia Lymphoma
Oncogenes
T-Lymphocytes
Gene Expression
Gene expression
Neoplasms

Keywords

  • ATL, HAM/TSP
  • Gene expression
  • Human T cell leukemia virus type I (HTLV-I)
  • ikk
  • NF-κB
  • NIK
  • p100
  • Signal transduction
  • Tax

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Mechanisms of persistent NF-κB activation by HTLV-I tax. / Harhaj, Edward W.; Harhaj, Nicole S.

In: IUBMB Life, Vol. 57, No. 2, 02.2005, p. 83-91.

Research output: Contribution to journalArticle

Harhaj, Edward W. ; Harhaj, Nicole S. / Mechanisms of persistent NF-κB activation by HTLV-I tax. In: IUBMB Life. 2005 ; Vol. 57, No. 2. pp. 83-91.
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