Mechanisms of Neuropathic Pain

Research output: Contribution to journalReview article

Abstract

Neuropathic pain refers to pain that originates from pathology of the nervous system. Diabetes, infection (herpes zoster), nerve compression, nerve trauma, "channelopathies," and autoimmune disease are examples of diseases that may cause neuropathic pain. The development of both animal models and newer pharmacological strategies has led to an explosion of interest in the underlying mechanisms. Neuropathic pain reflects both peripheral and central sensitization mechanisms. Abnormal signals arise not only from injured axons but also from the intact nociceptors that share the innervation territory of the injured nerve. This review focuses on how both human studies and animal models are helping to elucidate the mechanisms underlying these surprisingly common disorders. The rapid gain in knowledge about abnormal signaling promises breakthroughs in the treatment of these often debilitating disorders.

Original languageEnglish (US)
Pages (from-to)77-92
Number of pages16
JournalNeuron
Volume52
Issue number1
DOIs
StatePublished - Oct 5 2006

ASJC Scopus subject areas

  • Neuroscience(all)

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