Mechanisms of neuronal cell death in Huntington's disease

A. Sawa, T. Tomoda, B. I. Bae

Research output: Contribution to journalReview articlepeer-review

Abstract

Huntington's disease (HD) is a genetically dominant neurodegenerative condition caused by an unique mutation in the disease gene huntingtin. Although the Huntington protein (Htt) is ubiquitously expressed, expansion of the polyglutamine tract in Htt leads to the progressive loss of specific neuronal subpopulations in HD brains. In this article, we will summarize the current understanding on mechanisms of how mutant Htt can elicit cytotoxicity, as well as how the selective sets of neuronal cell death occur in HD brains.

Original languageEnglish (US)
Pages (from-to)287-295
Number of pages9
JournalCytogenetic and Genome Research
Volume100
Issue number1-4
DOIs
StatePublished - Dec 8 2003

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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