Mechanisms of neurodegeneration and therapeutics in animal models of neonatal hypoxic–ischemic encephalopathy

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Introduction Perinatal hypoxia–ischemia (HI) and asphyxia due to umbilical cord prolapse, delivery complications, airway obstruction, asthma, drowning, and cardiac arrest are significant causes of brain damage, mortality, and morbidity in infants and young children. The incidence of HI encephalopathy (HIE), for example, is ∼ 2 to 4/1000 live term births. Term infants that experience episodes of asphyxia can have damage in the brainstem and forebrain, with the basal ganglia, particularly the striatum, and somatosensory systems showing selective vulnerability. Infants surviving with HIE can have long-term neurological disability, including disorders in movement, visual deficits, learning and cognition impairments, and epilepsy. Many of these neurological disabilities are contributors to the complex clinical syndrome of cerebral palsy. Neuroimaging studies of full-term neonates and experimental studies on animal models suggest that this pattern of selective vulnerability is related to local metabolism and brain regional interconnections that instigate and propagate the damage within specific neural systems. This idea has been called the “metabolism-connectivity concept”. The neurodegeneration is partly triggered by excitotoxic mechanisms resulting from excessive activation of excitatory glutamate receptors and oxidative stress. The ion channel N-methyl-d-aspartate (NMDA) receptor and intracellular signaling networks involving calcium, nitric oxide synthase (NOS), mitochondria, and reactive oxygen species (ROS), such as superoxide, nitric oxide (NO), peroxynitrite, and hydrogen peroxide (H2O2), appear to have instrumental roles in the neuronal cell death leading to perinatal HIE.

Original languageEnglish (US)
Title of host publicationFetal and Neonatal Brain Injury, Fourth Edition
PublisherCambridge University Press
Pages14-37
Number of pages24
ISBN (Print)9780511581281, 9780521888592
DOIs
StatePublished - Jan 1 2009

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Brain Diseases
Animal Models
Asphyxia
Term Birth
Peroxynitrous Acid
Umbilical Cord
Prolapse
Movement Disorders
Glutamate Receptors
Brain
Live Birth
Airway Obstruction
Cerebral Palsy
Prosencephalon
Heart Arrest
Basal Ganglia
Ion Channels
Neuroimaging
Nitric Oxide Synthase
Superoxides

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mechanisms of neurodegeneration and therapeutics in animal models of neonatal hypoxic–ischemic encephalopathy. / Martin, Lee J.

Fetal and Neonatal Brain Injury, Fourth Edition. Cambridge University Press, 2009. p. 14-37.

Research output: Chapter in Book/Report/Conference proceedingChapter

Martin, Lee J. / Mechanisms of neurodegeneration and therapeutics in animal models of neonatal hypoxic–ischemic encephalopathy. Fetal and Neonatal Brain Injury, Fourth Edition. Cambridge University Press, 2009. pp. 14-37
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