Mechanisms of invasion and motility of high-grade gliomas in the brain

Devin B. Mair, Heather M. Ames, Rong Li

Research output: Contribution to journalReview article

Abstract

High-grade gliomas are especially difficult tumors to treat due to their invasive behavior. This has led to extensive research focusing on arresting glioma cell migration. Cell migration involves the sensing of a migratory cue, followed by polarization in the direction of the cue, and reorganization of the actin cytoskeleton to allow for a protrusive leading edge and a contractile trailing edge. Transmission of these forces to produce motility also requires adhesive interactions of the cell with the extracellular microenvironment. In glioma cells, transmembrane receptors such as CD44 and integrins bind the cell to the surrounding extracellular matrix that provides a substrate on which the cell can exert the requisite forces for cell motility. These various essential parts of the migratory machinery are potential targets to halt glioma cell invasion. In this review, we discuss the mechanisms of glioma cell migration and how they may be targeted in anti-invasion therapies.

Original languageEnglish (US)
Pages (from-to)2509-2515
Number of pages7
JournalMolecular biology of the cell
Volume29
Issue number21
DOIs
StatePublished - Oct 15 2018

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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