Mechanisms of immunosuppression in colorectal cancer

Yang Zhang, Ashwani Rajput, Ning Jin, Jing Wang

Research output: Contribution to journalReview articlepeer-review

Abstract

CRC is the third most diagnosed cancer in the US with the second-highest mortality rate. A multi-modality approach with surgery/chemotherapy is used in patients with early stages of colon cancer. Radiation therapy is added to the armamentarium in patients with locally advanced rectal cancer. While some patients with metastatic CRC are cured, the majority remain incurable and receive palliative chemotherapy as the standard of care. Recently, immune checkpoint blockade has emerged as a promising treatment for many solid tumors, including CRC with microsatellite instability. However, it has not been effective for microsatellite stable CRC. Here, main mechanisms of immunosuppression in CRC will be discussed, aiming to provide some insights for restoring immunosurveillance to improve treatment efficacy in CRC.

Original languageEnglish (US)
Article number3850
Pages (from-to)1-24
Number of pages24
JournalCancers
Volume12
Issue number12
DOIs
StatePublished - Dec 2020

Keywords

  • Cell surface protein
  • Colorectal cancer
  • Cytokine
  • Immunosuppression
  • Immunotherapy
  • Metabolic alteration
  • Microsatellite stable
  • Phosphatase
  • Transcriptional factor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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