Mechanisms of Immune Evasion by Tumors

Research output: Contribution to journalReview article

Abstract

In the past decade, basic studies in animal models have begun to elucidate the physiological barriers which impede a successful antitumor immune response. These barriers operate at a number of levels, and involve the tumor, the tumor microenvironment and various components of the innate and adaptive immune systems. In this review, we discuss the multiple mechanisms by which tumors evade an immune response, with an emphasis on clinically relevant strategies to overcome these inhibitory checkpoints.

Original languageEnglish (US)
Pages (from-to)51-81
Number of pages31
JournalAdvances in Immunology
Volume90
DOIs
StatePublished - May 29 2006

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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