Mechanisms of HIV-1 escape from immune responses and antiretroviral drugs

Justin Bailey; Joel N. Blankson; Megan Wind-Rotolo; Robert F. Siliciano

doi:10.1016/j.coi.2004.05.005

Mechanisms of HIV-1 escape from immune responses and antiretroviral drugs

Justin Bailey, Joel N. Blankson, Megan Wind-Rotolo, Robert F. Siliciano

Research output: Contribution to journal › Review article › peer-review

43 Scopus citations

Abstract

Despite the fact that HIV-1 induces vigorous antiviral immune responses, viral replication is never completely controlled in infected individuals. Recent studies have provided insight into the mechanisms by which focused immune pressure directed at particular B or T cell epitopes leads to the rapid appearance of escape mutations. Even if anti-HIV-1 immune responses could be enhanced to the point where they inhibit viral replication to the same extent as certain combinations of antiretroviral drugs, eradication would be unlikely because of the persistence of the virus in an extremely stable latent reservoir in resting memory CD4⁺ T cells.

Original language	English (US)
Pages (from-to)	470-476
Number of pages	7
Journal	Current Opinion in Immunology
Volume	16
Issue number	4
DOIs	https://doi.org/10.1016/j.coi.2004.05.005
State	Published - Aug 2004

Keywords

AIDS
CTL
HAART
HIV
HIV-1 envelope
IκB
MHC
acquired immunodeficiency syndrome
cytotoxic T lymphocyte
env
highly active antiretroviral therapy
human immunodeficiency virus
inhibitor of κB
major histocompatibility complex
nAb

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.coi.2004.05.005

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title = "Mechanisms of HIV-1 escape from immune responses and antiretroviral drugs",

abstract = "Despite the fact that HIV-1 induces vigorous antiviral immune responses, viral replication is never completely controlled in infected individuals. Recent studies have provided insight into the mechanisms by which focused immune pressure directed at particular B or T cell epitopes leads to the rapid appearance of escape mutations. Even if anti-HIV-1 immune responses could be enhanced to the point where they inhibit viral replication to the same extent as certain combinations of antiretroviral drugs, eradication would be unlikely because of the persistence of the virus in an extremely stable latent reservoir in resting memory CD4+ T cells.",

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AU - Bailey, Justin

AU - Blankson, Joel N.

AU - Wind-Rotolo, Megan

AU - Siliciano, Robert F.

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Y1 - 2004/8

N2 - Despite the fact that HIV-1 induces vigorous antiviral immune responses, viral replication is never completely controlled in infected individuals. Recent studies have provided insight into the mechanisms by which focused immune pressure directed at particular B or T cell epitopes leads to the rapid appearance of escape mutations. Even if anti-HIV-1 immune responses could be enhanced to the point where they inhibit viral replication to the same extent as certain combinations of antiretroviral drugs, eradication would be unlikely because of the persistence of the virus in an extremely stable latent reservoir in resting memory CD4+ T cells.

AB - Despite the fact that HIV-1 induces vigorous antiviral immune responses, viral replication is never completely controlled in infected individuals. Recent studies have provided insight into the mechanisms by which focused immune pressure directed at particular B or T cell epitopes leads to the rapid appearance of escape mutations. Even if anti-HIV-1 immune responses could be enhanced to the point where they inhibit viral replication to the same extent as certain combinations of antiretroviral drugs, eradication would be unlikely because of the persistence of the virus in an extremely stable latent reservoir in resting memory CD4+ T cells.

KW - AIDS

KW - CTL

KW - HAART

KW - HIV

KW - HIV-1 envelope

KW - IκB

KW - MHC

KW - acquired immunodeficiency syndrome

KW - cytotoxic T lymphocyte

KW - env

KW - highly active antiretroviral therapy

KW - human immunodeficiency virus

KW - inhibitor of κB

KW - major histocompatibility complex

KW - nAb

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DO - 10.1016/j.coi.2004.05.005

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JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

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ER -

Mechanisms of HIV-1 escape from immune responses and antiretroviral drugs

Abstract

Keywords

ASJC Scopus subject areas

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