Mechanisms of hair cell tuning

R. Fettiplace, Paul Albert Fuchs

Research output: Contribution to journalArticle

Abstract

Mechanosensory hair cells of the vertebrate inner ear contribute to acoustic tuning through feedback processes involving voltage-gated channels in the basolateral membrane and mechanotransduction channels in the apical hair bundle. The specific number and kinetics of calcium-activated (BK) potassium channels determine the resonant frequency of electrically tuned hair cells. Kinetic variation among BK channels may arise through alternative splicing of slo gene mRNA and combination with modulatory β subunits. The number of transduction channels and their rate of adaptation rise with hair cell response frequency along the cochlea's tonotopic axis. Calcium-dependent feedback onto transduction channels may underlie active hair bundle mechanics. The relative contributions of electrical and mechanical feedback to active tuning of hair cells may vary as a function of sound frequency.

Original languageEnglish (US)
Pages (from-to)809-834
Number of pages26
JournalAnnual Review of Physiology
Volume61
DOIs
StatePublished - 1999

Fingerprint

Large-Conductance Calcium-Activated Potassium Channels
Calcium-Activated Potassium Channels
Cochlea
Alternative Splicing
Inner Ear
Mechanics
Ion Channels
Acoustics
Vertebrates
Calcium
Messenger RNA
Genes

Keywords

  • Alternative splicing
  • Calcium
  • Calcium-activated potassium channel
  • Electrical tuning
  • Mechanotransduction

ASJC Scopus subject areas

  • Physiology

Cite this

Mechanisms of hair cell tuning. / Fettiplace, R.; Fuchs, Paul Albert.

In: Annual Review of Physiology, Vol. 61, 1999, p. 809-834.

Research output: Contribution to journalArticle

Fettiplace, R. ; Fuchs, Paul Albert. / Mechanisms of hair cell tuning. In: Annual Review of Physiology. 1999 ; Vol. 61. pp. 809-834.
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