Mechanisms of gonadal differentiation

Florence P. Haseltine; Susumo Ohno

doi:10.1126/science.7010601

Mechanisms of gonadal differentiation

Florence P. Haseltine, Susumo Ohno

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Sex differentiation is the result of the translation of genetic sex into gonadal sex. Without recognizable masculinizing signals the embryonic gonad will undergo ovarian differentiation. The main determinant of gonadal differentiation appears to be the presence or absence of a cell surface antigen, called H-Y antigen. The regulation of H-Y antigen expression is complex and involves the interaction between regulatory sites on the Y chromosome, the X chromosome, and possibly the autosomes.

Original language	English (US)
Pages (from-to)	1272-1278
Number of pages	7
Journal	Science
Volume	211
Issue number	4488
DOIs	https://doi.org/10.1126/science.7010601
State	Published - 1981
Externally published	Yes

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10.1126/science.7010601

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title = "Mechanisms of gonadal differentiation",

abstract = "Sex differentiation is the result of the translation of genetic sex into gonadal sex. Without recognizable masculinizing signals the embryonic gonad will undergo ovarian differentiation. The main determinant of gonadal differentiation appears to be the presence or absence of a cell surface antigen, called H-Y antigen. The regulation of H-Y antigen expression is complex and involves the interaction between regulatory sites on the Y chromosome, the X chromosome, and possibly the autosomes.",

author = "Haseltine, {Florence P.} and Susumo Ohno",

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AB - Sex differentiation is the result of the translation of genetic sex into gonadal sex. Without recognizable masculinizing signals the embryonic gonad will undergo ovarian differentiation. The main determinant of gonadal differentiation appears to be the presence or absence of a cell surface antigen, called H-Y antigen. The regulation of H-Y antigen expression is complex and involves the interaction between regulatory sites on the Y chromosome, the X chromosome, and possibly the autosomes.

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Mechanisms of gonadal differentiation

Abstract

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