Mechanisms of gonadal differentiation

Florence P. Haseltine, Susumo Ohno

Research output: Contribution to journalArticlepeer-review


Sex differentiation is the result of the translation of genetic sex into gonadal sex. Without recognizable masculinizing signals the embryonic gonad will undergo ovarian differentiation. The main determinant of gonadal differentiation appears to be the presence or absence of a cell surface antigen, called H-Y antigen. The regulation of H-Y antigen expression is complex and involves the interaction between regulatory sites on the Y chromosome, the X chromosome, and possibly the autosomes.

Original languageEnglish (US)
Pages (from-to)1272-1278
Number of pages7
Issue number4488
StatePublished - 1981

ASJC Scopus subject areas

  • General


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