Mechanisms of chemoprotection by oltipraz

Thomas Kensier, Peter Stcyzynski, John Groopman, Kathy Helzlsouer, Thomas Curphey, Yulla Maxcultenko, B. D. Roebuck

Research output: Contribution to journalArticlepeer-review

Abstract

1,2‐Dithiole‐3‐thiones are five‐membered cyclic sulfur‐containing compounds with antioxidant, chemotherapeutic, radioprotective and cancer chemopretective properties. One substituted dithiolethione, oltipraz [5‐(2‐pyrazinyl)‐4‐methyl‐1,2‐dithiole‐3‐thione], originally developed as an antischistosomal agent, has recently been observed to protect against chemically induced carcinogenesis in lung, trachea, forestomach, colon, breast, liver and urinary bladder in rodents. The induction of electrophilic detoxication enzymes, which result in diminisehd carcinogen‐DNA adduct formation are reduced cytotoxicity, appears to be an important component of the anticarcinogenic action of oltipraz and other dithiolethiones. Phase I trials of oltipraz are presently underway in the United States. Subsequent trials might be most appropriately targeted towards individuals at high risk for occupational or environmental exposures to genotoxic carciongens. © 1992 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)167-172
Number of pages6
JournalJournal of cellular biochemistry
Volume50
Issue numberS16I
DOIs
StatePublished - 1992

Keywords

  • 1,2‐dithiole‐3‐thiones
  • DNA adducts
  • Oltipraz
  • S‐transferases
  • antischistosomiasis
  • carcinogen detoxication
  • enzyme induction
  • glutathione

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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