Abstract
The available data strongly suggest that CsA has a sparing effect on the activation and establishment of suppressor cell regulatory mechanisms while inhibiting cytotoxic T lymphocyte generation in response to transplantation antigens. This process appears to be mediated by several key events: (1) Inhibition of IL 2 production, (2) prevention of cytotoxic T cell sensitization, and (3) sparing of suppressor T cell activation and amplification.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 29-40 |
| Number of pages | 12 |
| Journal | Transplantation Proceedings |
| Volume | 20 |
| Issue number | 2 SUPPL. 2 |
| Publication status | Published - 1988 |
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ASJC Scopus subject areas
- Surgery
- Transplantation
Cite this
Hess, A. D., Esa, A. H., & Colombani, P. (1988). Mechanisms of action of cyclosporine: Effect on cells of the immune system and on subcellular events in T cell activation. Transplantation Proceedings, 20(2 SUPPL. 2), 29-40.