Mechanisms of action of cyclosporine: Effect on cells of the immune system and on subcellular events in T cell activation

A. D. Hess, A. H. Esa, Paul Colombani

Research output: Contribution to journalArticle


The available data strongly suggest that CsA has a sparing effect on the activation and establishment of suppressor cell regulatory mechanisms while inhibiting cytotoxic T lymphocyte generation in response to transplantation antigens. This process appears to be mediated by several key events: (1) Inhibition of IL 2 production, (2) prevention of cytotoxic T cell sensitization, and (3) sparing of suppressor T cell activation and amplification.

Original languageEnglish (US)
Pages (from-to)29-40
Number of pages12
JournalTransplantation Proceedings
Issue number2 SUPPL. 2
Publication statusPublished - 1988


ASJC Scopus subject areas

  • Surgery
  • Transplantation

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