Abstract
The available data strongly suggest that CsA has a sparing effect on the activation and establishment of suppressor cell regulatory mechanisms while inhibiting cytotoxic T lymphocyte generation in response to transplantation antigens. This process appears to be mediated by several key events: (1) Inhibition of IL 2 production, (2) prevention of cytotoxic T cell sensitization, and (3) sparing of suppressor T cell activation and amplification.
Original language | English (US) |
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Pages (from-to) | 29-40 |
Number of pages | 12 |
Journal | Transplantation proceedings |
Volume | 20 |
Issue number | 2 SUPPL. 2 |
State | Published - 1988 |
ASJC Scopus subject areas
- Surgery
- Transplantation