Mechanisms of action of cyclosporine: Effect on cells of the immune system and on subcellular events in T cell activation

A. D. Hess; A. H. Esa; P. M. Colombani

Mechanisms of action of cyclosporine: Effect on cells of the immune system and on subcellular events in T cell activation

A. D. Hess, A. H. Esa, P. M. Colombani

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

The available data strongly suggest that CsA has a sparing effect on the activation and establishment of suppressor cell regulatory mechanisms while inhibiting cytotoxic T lymphocyte generation in response to transplantation antigens. This process appears to be mediated by several key events: (1) Inhibition of IL 2 production, (2) prevention of cytotoxic T cell sensitization, and (3) sparing of suppressor T cell activation and amplification.

Original language	English (US)
Pages (from-to)	29-40
Number of pages	12
Journal	Transplantation proceedings
Volume	20
Issue number	2 SUPPL. 2
State	Published - 1988

ASJC Scopus subject areas

Surgery
Transplantation

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title = "Mechanisms of action of cyclosporine: Effect on cells of the immune system and on subcellular events in T cell activation",

abstract = "The available data strongly suggest that CsA has a sparing effect on the activation and establishment of suppressor cell regulatory mechanisms while inhibiting cytotoxic T lymphocyte generation in response to transplantation antigens. This process appears to be mediated by several key events: (1) Inhibition of IL 2 production, (2) prevention of cytotoxic T cell sensitization, and (3) sparing of suppressor T cell activation and amplification.",

author = "Hess, {A. D.} and Esa, {A. H.} and Colombani, {P. M.}",

year = "1988",

language = "English (US)",

volume = "20",

pages = "29--40",

journal = "Transplantation Proceedings",

issn = "0041-1345",

publisher = "Elsevier USA",

number = "2 SUPPL. 2",

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T2 - Effect on cells of the immune system and on subcellular events in T cell activation

AU - Hess, A. D.

AU - Esa, A. H.

AU - Colombani, P. M.

PY - 1988

Y1 - 1988

N2 - The available data strongly suggest that CsA has a sparing effect on the activation and establishment of suppressor cell regulatory mechanisms while inhibiting cytotoxic T lymphocyte generation in response to transplantation antigens. This process appears to be mediated by several key events: (1) Inhibition of IL 2 production, (2) prevention of cytotoxic T cell sensitization, and (3) sparing of suppressor T cell activation and amplification.

AB - The available data strongly suggest that CsA has a sparing effect on the activation and establishment of suppressor cell regulatory mechanisms while inhibiting cytotoxic T lymphocyte generation in response to transplantation antigens. This process appears to be mediated by several key events: (1) Inhibition of IL 2 production, (2) prevention of cytotoxic T cell sensitization, and (3) sparing of suppressor T cell activation and amplification.

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M3 - Review article

C2 - 2834840

AN - SCOPUS:0023944434

VL - 20

SP - 29

EP - 40

JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

IS - 2 SUPPL. 2

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