The available data strongly suggest that CsA has a sparing effect on the activation and establishment of suppressor cell regulatory mechanisms while inhibiting cytotoxic T lymphocyte generation in response to transplantation antigens. This process appears to be mediated by several key events: (1) Inhibition of IL 2 production, (2) prevention of cytotoxic T cell sensitization, and (3) sparing of suppressor T cell activation and amplification.
|Original language||English (US)|
|Number of pages||12|
|Issue number||2 SUPPL. 2|
|Publication status||Published - 1988|
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