Mechanisms involved in antibody- and complement-mediated allograft rejection

Barbara A. Wasowska

Research output: Contribution to journalArticle

Abstract

Antibody-mediated rejection has become critical clinically because this form of rejection is usually unresponsive to conventional anti-rejection therapy, and therefore, it has been recognized as a major cause of allograft loss. Our group developed experimental animal models of vascularized organ transplantation to study pathogenesis of antibody- and complement-mediated endothelial cell injury leading to graft rejection. In this review, we discuss mechanisms of antibody-mediated graft rejection resulting from activation of complement by C1q- and MBL (mannose-binding lectin)-dependent pathways and interactions with a variety of effector cells, including macrophages and monocytes through Fcγ receptors and complement receptors.

Original languageEnglish (US)
Pages (from-to)25-44
Number of pages20
JournalImmunologic Research
Volume47
Issue number1-3
DOIs
StatePublished - Jul 2010

Keywords

  • Alloantibody
  • C4d
  • Cardiac rejection
  • Complement
  • Endothelial cells
  • Fcγ and complement receptors
  • Ig knockout mice
  • Macrophages
  • MBL
  • vWf

ASJC Scopus subject areas

  • Immunology
  • Medicine(all)

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