Abstract
Live antibody-coated Trypanosoma brucei parasites remove variable surface glycoprotein (VSG)-antibody complexes from their surface upon warming to 37° C and evade antibody-activated complement lysis by both protein synthesis-dependent and protein synthesis-independent mechanisms. The protein synthesis-dependent process follows antibody-mediated trypanosome agglutination, whereas the protein synthesis-independent mechanism can occur in the absence of trypanosome agglutination. The latter process leads to a more rapid climination of complement-fixing VSG-antibody complexes.
Original language | English (US) |
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Pages (from-to) | 487-492 |
Number of pages | 6 |
Journal | Parasitology Research |
Volume | 80 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1994 |
Externally published | Yes |
ASJC Scopus subject areas
- Parasitology