Mechanisms for the elimination of potentially lytic complement-fixing variable surface glycoprotein antibody-complexes in Trypanosoma brucei

D. C W Russo, D. J L Williams, D. J. Grab

Research output: Contribution to journalArticlepeer-review

Abstract

Live antibody-coated Trypanosoma brucei parasites remove variable surface glycoprotein (VSG)-antibody complexes from their surface upon warming to 37° C and evade antibody-activated complement lysis by both protein synthesis-dependent and protein synthesis-independent mechanisms. The protein synthesis-dependent process follows antibody-mediated trypanosome agglutination, whereas the protein synthesis-independent mechanism can occur in the absence of trypanosome agglutination. The latter process leads to a more rapid climination of complement-fixing VSG-antibody complexes.

Original languageEnglish (US)
Pages (from-to)487-492
Number of pages6
JournalParasitology Research
Volume80
Issue number6
DOIs
StatePublished - Jun 1994
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology

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