Mechanisms for the association of gastroesophageal reflux and bronchospasm.

J. T. Boyle, D. N. Tuchman, S. M. Altschuler, T. E. Nixon, A. I. Pack, S. Cohen

Research output: Contribution to journalArticle

Abstract

The mechanism for the association between gastroesophageal reflux and bronchospasm is probably multifactorial. Our data support the view that microaspiration into the trachea may be an important mechanism for bronchospasm induced by gastroesophageal reflux and needs to be distinguished from simple reflux into the esophagus. Intraesophageal acidification alone quantitatively produces a much smaller airway response than does intratracheal acidification. A challenge test should be developed to correlate airway response following intraesophageal acidification to airway hyperactivity. We believe that the relationship of the diaphragm to the antireflux barrier deserves further study.

Original languageEnglish (US)
JournalAmerican Review of Respiratory Disease
Volume131
Issue number5
StatePublished - May 1985
Externally publishedYes

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Bronchial Spasm
Gastroesophageal Reflux
Diaphragm
Trachea
Esophagus

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Boyle, J. T., Tuchman, D. N., Altschuler, S. M., Nixon, T. E., Pack, A. I., & Cohen, S. (1985). Mechanisms for the association of gastroesophageal reflux and bronchospasm. American Review of Respiratory Disease, 131(5).

Mechanisms for the association of gastroesophageal reflux and bronchospasm. / Boyle, J. T.; Tuchman, D. N.; Altschuler, S. M.; Nixon, T. E.; Pack, A. I.; Cohen, S.

In: American Review of Respiratory Disease, Vol. 131, No. 5, 05.1985.

Research output: Contribution to journalArticle

Boyle, JT, Tuchman, DN, Altschuler, SM, Nixon, TE, Pack, AI & Cohen, S 1985, 'Mechanisms for the association of gastroesophageal reflux and bronchospasm.', American Review of Respiratory Disease, vol. 131, no. 5.
Boyle JT, Tuchman DN, Altschuler SM, Nixon TE, Pack AI, Cohen S. Mechanisms for the association of gastroesophageal reflux and bronchospasm. American Review of Respiratory Disease. 1985 May;131(5).
Boyle, J. T. ; Tuchman, D. N. ; Altschuler, S. M. ; Nixon, T. E. ; Pack, A. I. ; Cohen, S. / Mechanisms for the association of gastroesophageal reflux and bronchospasm. In: American Review of Respiratory Disease. 1985 ; Vol. 131, No. 5.
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