Abstract
Sleep disturbance is prevalent in aging and painful rheumatologic populations, but it has largely been a neglected dimension of the routine clinical care of arthritis patients. Pain associated with osteoarthritis (OA) is a leading cause of disability worldwide, and factors that contribute to pain in OA are poorly understood. Sleep disturbance is not only a consequence of pain, it is also likely to play an integral role in pain expression. Emerging research suggests that many patients with OA demonstrate signs of generalized hyperalgesia and faulty central pain modulatory processing similar to other idiopathic pain disorders, such as fibromyalgia. Sleep disruption is increasingly recognized as a direct contributor to both hyperalgesia and impaired endogenous pain modulation. This article reviews the extant literature on sleep disturbance and hyperalgesia in patients with OA. We propose a conceptual working model describing pathways by which sleep disturbance interacts directly with central pain processing mechanisms and inflammatory processes, and indirectly with mood and physical functioning to augment clinical OA pain. The clinical and research implications of the model are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 447-454 |
| Number of pages | 8 |
| Journal | Current Pain and Headache Reports |
| Volume | 13 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 2009 |
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ASJC Scopus subject areas
- Clinical Neurology
- Anesthesiology and Pain Medicine
Cite this
Mechanisms by which sleep disturbance contributes to osteoarthritis pain : A conceptual model. / Smith, Michael T; Quartana, Phillip J.; Okonkwo, Renata M.; Nasir, Adeel.
In: Current Pain and Headache Reports, Vol. 13, No. 6, 12.2009, p. 447-454.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mechanisms by which sleep disturbance contributes to osteoarthritis pain
T2 - A conceptual model
AU - Smith, Michael T
AU - Quartana, Phillip J.
AU - Okonkwo, Renata M.
AU - Nasir, Adeel
PY - 2009/12
Y1 - 2009/12
N2 - Sleep disturbance is prevalent in aging and painful rheumatologic populations, but it has largely been a neglected dimension of the routine clinical care of arthritis patients. Pain associated with osteoarthritis (OA) is a leading cause of disability worldwide, and factors that contribute to pain in OA are poorly understood. Sleep disturbance is not only a consequence of pain, it is also likely to play an integral role in pain expression. Emerging research suggests that many patients with OA demonstrate signs of generalized hyperalgesia and faulty central pain modulatory processing similar to other idiopathic pain disorders, such as fibromyalgia. Sleep disruption is increasingly recognized as a direct contributor to both hyperalgesia and impaired endogenous pain modulation. This article reviews the extant literature on sleep disturbance and hyperalgesia in patients with OA. We propose a conceptual working model describing pathways by which sleep disturbance interacts directly with central pain processing mechanisms and inflammatory processes, and indirectly with mood and physical functioning to augment clinical OA pain. The clinical and research implications of the model are discussed.
AB - Sleep disturbance is prevalent in aging and painful rheumatologic populations, but it has largely been a neglected dimension of the routine clinical care of arthritis patients. Pain associated with osteoarthritis (OA) is a leading cause of disability worldwide, and factors that contribute to pain in OA are poorly understood. Sleep disturbance is not only a consequence of pain, it is also likely to play an integral role in pain expression. Emerging research suggests that many patients with OA demonstrate signs of generalized hyperalgesia and faulty central pain modulatory processing similar to other idiopathic pain disorders, such as fibromyalgia. Sleep disruption is increasingly recognized as a direct contributor to both hyperalgesia and impaired endogenous pain modulation. This article reviews the extant literature on sleep disturbance and hyperalgesia in patients with OA. We propose a conceptual working model describing pathways by which sleep disturbance interacts directly with central pain processing mechanisms and inflammatory processes, and indirectly with mood and physical functioning to augment clinical OA pain. The clinical and research implications of the model are discussed.
UR - http://www.scopus.com/inward/record.url?scp=70449511667&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70449511667&partnerID=8YFLogxK
U2 - 10.1007/s11916-009-0073-2
DO - 10.1007/s11916-009-0073-2
M3 - Article
C2 - 19889286
AN - SCOPUS:70449511667
VL - 13
SP - 447
EP - 454
JO - Current Pain and Headache Reports
JF - Current Pain and Headache Reports
SN - 1531-3433
IS - 6
ER -