Mechanisms and potential therapeutic targets for folic acid in cardiovascular disease

An L. Moens, Christiaan J. Vrints, Marc J. Claeys, Jean Pierre Timmermans, Hunter C. Champion, David A Kass

Research output: Contribution to journalArticle

Abstract

Folic acid (FA) is a member of the B-vitamin family with cardiovascular roles in homocysteine regulation and endothelial nitric oxide synthase (eNOS) activity. Its interaction with eNOS is thought to be due to the enhancement of tetrahydrobiopterin bioavailability, helping maintain eNOS in its coupled state to favor the generation of nitric oxide rather than oxygen free radicals. FA also plays a role in the prevention of several cardiac and noncardiac malformations, has potent direct antioxidant and antithrombotic effects, and can interfere with the production of the endothelial-derived hyperpolarizing factor. These multiple mechanisms of action have led to studies regarding the therapeutic potential of FA in cardiovascular disease. To date, studies have demonstrated that FA ameliorates endothelial dysfunction and nitrate tolerance and can improve pathological features of atherosclerosis. These effects appear to be homocysteine independent but rather related to their role in eNOS function. Given the growing evidence that nitric oxide synthase uncoupling plays a major role in many cardiovascular disorders, the potential of exogenous FA as an inexpensive and safe oral therapy is intriguing and is stimulating ongoing investigations.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume294
Issue number5
DOIs
StatePublished - May 2008

Fingerprint

Folic Acid
Nitric Oxide Synthase Type III
Cardiovascular Diseases
Homocysteine
Therapeutics
Vitamin B Complex
Nitric Oxide Synthase
Nitrates
Biological Availability
Free Radicals
Reactive Oxygen Species
Atherosclerosis
Nitric Oxide
Antioxidants

Keywords

  • Endothelial nitric oxide synthase
  • Homocysteine
  • Superoxide
  • Tetrahydrobiopterin
  • Uncoupling

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Mechanisms and potential therapeutic targets for folic acid in cardiovascular disease. / Moens, An L.; Vrints, Christiaan J.; Claeys, Marc J.; Timmermans, Jean Pierre; Champion, Hunter C.; Kass, David A.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 294, No. 5, 05.2008.

Research output: Contribution to journalArticle

Moens, An L. ; Vrints, Christiaan J. ; Claeys, Marc J. ; Timmermans, Jean Pierre ; Champion, Hunter C. ; Kass, David A. / Mechanisms and potential therapeutic targets for folic acid in cardiovascular disease. In: American Journal of Physiology - Heart and Circulatory Physiology. 2008 ; Vol. 294, No. 5.
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