Mechanism of Tumor Inhibition by Estrogen

Morton F. Goldberg; Abram Tregier; Milton S. Grossman

doi:10.3181/00379727-102-25266

Mechanism of Tumor Inhibition by Estrogen

Morton F. Goldberg, Abram Tregier, Milton S. Grossman

Research output: Contribution to journal › Article › peer-review

Abstract

Immature AKD2F₁ mice were examined for possible estrogenic inhibition of Sarcoma 1. Large doses of estradiol benzoate inhibited growth of tumor in intact animals and in hysterectomized castrates. It was concluded that this estrogenic effect can be achieved in absence of uterus, and that the tumor-inhibitory properties of endometrial secretions act by a mechanism different from that of estrogen.

Original language	English (US)
Pages (from-to)	408-410
Number of pages	3
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	102
Issue number	2
DOIs	https://doi.org/10.3181/00379727-102-25266
State	Published - Nov 1959
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.3181/00379727-102-25266

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title = "Mechanism of Tumor Inhibition by Estrogen",

abstract = "Immature AKD2F1 mice were examined for possible estrogenic inhibition of Sarcoma 1. Large doses of estradiol benzoate inhibited growth of tumor in intact animals and in hysterectomized castrates. It was concluded that this estrogenic effect can be achieved in absence of uterus, and that the tumor-inhibitory properties of endometrial secretions act by a mechanism different from that of estrogen.",

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year = "1959",

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AU - Goldberg, Morton F.

AU - Tregier, Abram

AU - Grossman, Milton S.

PY - 1959/11

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AB - Immature AKD2F1 mice were examined for possible estrogenic inhibition of Sarcoma 1. Large doses of estradiol benzoate inhibited growth of tumor in intact animals and in hysterectomized castrates. It was concluded that this estrogenic effect can be achieved in absence of uterus, and that the tumor-inhibitory properties of endometrial secretions act by a mechanism different from that of estrogen.

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JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)

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Mechanism of Tumor Inhibition by Estrogen

Abstract

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