Mechanism of the nuclear receptor molecular switch

Laszlo Nagy, John W.R. Schwabe

Research output: Contribution to journalReview articlepeer-review

Abstract

Nuclear receptors are central to the regulation of development, endocrine signalling and metabolism. The transcriptional activity of many receptors is controlled through the binding of small, fat-soluble molecules to the ligand-binding domain. In most cases, ligand binding turns the receptors into potent activators of transcription. This switch involves the exchange of co-regulator proteins that mediate transcriptional regulation. Structural and biochemical studies have together revealed the mechanism of action of this ligand-induced molecular switch, in which changes in the dynamic behaviour of the receptor play a key role. This remarkable dynamic mechanism has facilitated the evolution of a family of nuclear receptors with highly diverse ligand recognition and signalling properties.

Original languageEnglish (US)
Pages (from-to)317-324
Number of pages8
JournalTrends in biochemical sciences
Volume29
Issue number6
DOIs
StatePublished - Jun 2004
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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