Mechanism of the nuclear receptor molecular switch

Laszlo Nagy, John W.R. Schwabe

Research output: Contribution to journalReview article

Abstract

Nuclear receptors are central to the regulation of development, endocrine signalling and metabolism. The transcriptional activity of many receptors is controlled through the binding of small, fat-soluble molecules to the ligand-binding domain. In most cases, ligand binding turns the receptors into potent activators of transcription. This switch involves the exchange of co-regulator proteins that mediate transcriptional regulation. Structural and biochemical studies have together revealed the mechanism of action of this ligand-induced molecular switch, in which changes in the dynamic behaviour of the receptor play a key role. This remarkable dynamic mechanism has facilitated the evolution of a family of nuclear receptors with highly diverse ligand recognition and signalling properties.

Original languageEnglish (US)
Pages (from-to)317-324
Number of pages8
JournalTrends in Biochemical Sciences
Volume29
Issue number6
DOIs
StatePublished - Jun 1 2004
Externally publishedYes

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Cytoplasmic and Nuclear Receptors
Switches
Ligands
Transcription
Metabolism
Fats
Molecules
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Mechanism of the nuclear receptor molecular switch. / Nagy, Laszlo; Schwabe, John W.R.

In: Trends in Biochemical Sciences, Vol. 29, No. 6, 01.06.2004, p. 317-324.

Research output: Contribution to journalReview article

Nagy, Laszlo ; Schwabe, John W.R. / Mechanism of the nuclear receptor molecular switch. In: Trends in Biochemical Sciences. 2004 ; Vol. 29, No. 6. pp. 317-324.
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