Mechanism of suppression of cell-mediated immunity by measles virus

Christopher L. Karp; Maria Wysocka; Larry M. Wahl; Joseph M. Ahearn; Peter J. Cuomo; Barbara Sherry; Giorgio Trinchieri; Diane E. Griffin

doi:10.1126/science.273.5272.228

Mechanism of suppression of cell-mediated immunity by measles virus

Christopher L. Karp, Maria Wysocka, Larry M. Wahl, Joseph M. Ahearn, Peter J. Cuomo, Barbara Sherry, Giorgio Trinchieri, Diane E. Griffin

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

472 Scopus citations

Abstract

The mechanisms underlying the profound suppression of cell-mediated immunity (CMI) accompanying measles are unclear. Interleukin-12 (IL-12), derived principally from monocytes and macrophages, is critical for the generation of CMI. Measles virus (MV) infection of primary human monocytes specifically down-regulated IL-12 production. Cross-linking of CD46, a complement regulatory protein that is the cellular receptor for MV, with antibody or with the complement activation product C3b similarly inhibited monocyte IL-12 production, providing a plausible mechanism for MV-induced immunosuppression. CD46 provides a regulatory link between the complement system and cellular immune responses.

Original language	English (US)
Pages (from-to)	228-231
Number of pages	4
Journal	Science
Volume	273
Issue number	5272
DOIs	https://doi.org/10.1126/science.273.5272.228
State	Published - Jul 12 1996

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title = "Mechanism of suppression of cell-mediated immunity by measles virus",

abstract = "The mechanisms underlying the profound suppression of cell-mediated immunity (CMI) accompanying measles are unclear. Interleukin-12 (IL-12), derived principally from monocytes and macrophages, is critical for the generation of CMI. Measles virus (MV) infection of primary human monocytes specifically down-regulated IL-12 production. Cross-linking of CD46, a complement regulatory protein that is the cellular receptor for MV, with antibody or with the complement activation product C3b similarly inhibited monocyte IL-12 production, providing a plausible mechanism for MV-induced immunosuppression. CD46 provides a regulatory link between the complement system and cellular immune responses.",

author = "Karp, {Christopher L.} and Maria Wysocka and Wahl, {Larry M.} and Ahearn, {Joseph M.} and Cuomo, {Peter J.} and Barbara Sherry and Giorgio Trinchieri and Griffin, {Diane E.}",

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T1 - Mechanism of suppression of cell-mediated immunity by measles virus

AU - Karp, Christopher L.

AU - Wysocka, Maria

AU - Wahl, Larry M.

AU - Ahearn, Joseph M.

AU - Cuomo, Peter J.

AU - Sherry, Barbara

AU - Trinchieri, Giorgio

AU - Griffin, Diane E.

PY - 1996/7/12

Y1 - 1996/7/12

N2 - The mechanisms underlying the profound suppression of cell-mediated immunity (CMI) accompanying measles are unclear. Interleukin-12 (IL-12), derived principally from monocytes and macrophages, is critical for the generation of CMI. Measles virus (MV) infection of primary human monocytes specifically down-regulated IL-12 production. Cross-linking of CD46, a complement regulatory protein that is the cellular receptor for MV, with antibody or with the complement activation product C3b similarly inhibited monocyte IL-12 production, providing a plausible mechanism for MV-induced immunosuppression. CD46 provides a regulatory link between the complement system and cellular immune responses.

AB - The mechanisms underlying the profound suppression of cell-mediated immunity (CMI) accompanying measles are unclear. Interleukin-12 (IL-12), derived principally from monocytes and macrophages, is critical for the generation of CMI. Measles virus (MV) infection of primary human monocytes specifically down-regulated IL-12 production. Cross-linking of CD46, a complement regulatory protein that is the cellular receptor for MV, with antibody or with the complement activation product C3b similarly inhibited monocyte IL-12 production, providing a plausible mechanism for MV-induced immunosuppression. CD46 provides a regulatory link between the complement system and cellular immune responses.

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Mechanism of suppression of cell-mediated immunity by measles virus

Abstract

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