Mechanism of suppression of cell-mediated immunity by measles virus

Christopher L. Karp, Maria Wysocka, Larry M. Wahl, Joseph M. Ahearn, Peter J. Cuomo, Barbara Sherry, Giorgio Trinchieri, Diane E. Griffin

Research output: Contribution to journalArticlepeer-review

Abstract

The mechanisms underlying the profound suppression of cell-mediated immunity (CMI) accompanying measles are unclear. Interleukin-12 (IL-12), derived principally from monocytes and macrophages, is critical for the generation of CMI. Measles virus (MV) infection of primary human monocytes specifically down-regulated IL-12 production. Cross-linking of CD46, a complement regulatory protein that is the cellular receptor for MV, with antibody or with the complement activation product C3b similarly inhibited monocyte IL-12 production, providing a plausible mechanism for MV-induced immunosuppression. CD46 provides a regulatory link between the complement system and cellular immune responses.

Original languageEnglish (US)
Pages (from-to)228-231
Number of pages4
JournalScience
Volume273
Issue number5272
DOIs
StatePublished - Jul 12 1996

ASJC Scopus subject areas

  • General

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