Mechanism of pathological changes in stroke: Role of PSD93 in neuron injury induced by platelet activating factor

Rong Huang; Yun Xu; Lan Wang; Lin Zhu; Chong Wang; De Ning Guan; Zhong Yuan Wang; Yuan Xiang Tao

Mechanism of pathological changes in stroke: Role of PSD93 in neuron injury induced by platelet activating factor

Rong Huang, Yun Xu, Lan Wang, Lin Zhu, Chong Wang, De Ning Guan, Zhong Yuan Wang, Yuan Xiang Tao

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: To investigate whether PSD93 participates in the neurotoxity induced by platelet activating factor (PAF) so as to study the molecular mechanism of neuron injury due to PAF. Methods: The experiment was done in the Department of Neurology, Nanjing Drum Tower Hospital, and Dr. Tao Laboratory of the John Hopkins University from May 2003 to May 2004. PAF treated the cortical neurons of wild type and PSD93 knock out mice, and the cells were stained with propidium iodide/Calcein AM for apoptosis. Results: Neurotoxicity was obviously found in the cortical neurons of wild type and PSD93 knock out mice after treatment with 0.10, 0.30, 0.6 μmol/L PAP (P < 0.05). The apoptosis of cortical neurons in the PSD93 knock out mice was significantly lower than that in the wild type (P < 0.01). Conclusion: PSD93 knock out can protect cortical neurons from PAF-induced damage.

Original language	English (US)
Pages (from-to)	104-105
Number of pages	2
Journal	Chinese Journal of Clinical Rehabilitation
Volume	9
Issue number	1
State	Published - Jan 2005
Externally published	Yes

ASJC Scopus subject areas

Rehabilitation

Cite this

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title = "Mechanism of pathological changes in stroke: Role of PSD93 in neuron injury induced by platelet activating factor",

abstract = "Aim: To investigate whether PSD93 participates in the neurotoxity induced by platelet activating factor (PAF) so as to study the molecular mechanism of neuron injury due to PAF. Methods: The experiment was done in the Department of Neurology, Nanjing Drum Tower Hospital, and Dr. Tao Laboratory of the John Hopkins University from May 2003 to May 2004. PAF treated the cortical neurons of wild type and PSD93 knock out mice, and the cells were stained with propidium iodide/Calcein AM for apoptosis. Results: Neurotoxicity was obviously found in the cortical neurons of wild type and PSD93 knock out mice after treatment with 0.10, 0.30, 0.6 μmol/L PAP (P < 0.05). The apoptosis of cortical neurons in the PSD93 knock out mice was significantly lower than that in the wild type (P < 0.01). Conclusion: PSD93 knock out can protect cortical neurons from PAF-induced damage.",

author = "Rong Huang and Yun Xu and Lan Wang and Lin Zhu and Chong Wang and Guan, {De Ning} and Wang, {Zhong Yuan} and Tao, {Yuan Xiang}",

year = "2005",

month = jan,

language = "English (US)",

volume = "9",

pages = "104--105",

journal = "Chinese Journal of Clinical Rehabilitation",

issn = "1671-5926",

publisher = "Zhongguo Lin Chuang Kang Fu",

number = "1",

}

TY - JOUR

T1 - Mechanism of pathological changes in stroke

T2 - Role of PSD93 in neuron injury induced by platelet activating factor

AU - Huang, Rong

AU - Xu, Yun

AU - Wang, Lan

AU - Zhu, Lin

AU - Wang, Chong

AU - Guan, De Ning

AU - Wang, Zhong Yuan

AU - Tao, Yuan Xiang

PY - 2005/1

Y1 - 2005/1

N2 - Aim: To investigate whether PSD93 participates in the neurotoxity induced by platelet activating factor (PAF) so as to study the molecular mechanism of neuron injury due to PAF. Methods: The experiment was done in the Department of Neurology, Nanjing Drum Tower Hospital, and Dr. Tao Laboratory of the John Hopkins University from May 2003 to May 2004. PAF treated the cortical neurons of wild type and PSD93 knock out mice, and the cells were stained with propidium iodide/Calcein AM for apoptosis. Results: Neurotoxicity was obviously found in the cortical neurons of wild type and PSD93 knock out mice after treatment with 0.10, 0.30, 0.6 μmol/L PAP (P < 0.05). The apoptosis of cortical neurons in the PSD93 knock out mice was significantly lower than that in the wild type (P < 0.01). Conclusion: PSD93 knock out can protect cortical neurons from PAF-induced damage.

AB - Aim: To investigate whether PSD93 participates in the neurotoxity induced by platelet activating factor (PAF) so as to study the molecular mechanism of neuron injury due to PAF. Methods: The experiment was done in the Department of Neurology, Nanjing Drum Tower Hospital, and Dr. Tao Laboratory of the John Hopkins University from May 2003 to May 2004. PAF treated the cortical neurons of wild type and PSD93 knock out mice, and the cells were stained with propidium iodide/Calcein AM for apoptosis. Results: Neurotoxicity was obviously found in the cortical neurons of wild type and PSD93 knock out mice after treatment with 0.10, 0.30, 0.6 μmol/L PAP (P < 0.05). The apoptosis of cortical neurons in the PSD93 knock out mice was significantly lower than that in the wild type (P < 0.01). Conclusion: PSD93 knock out can protect cortical neurons from PAF-induced damage.

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SN - 1671-5926

VL - 9

SP - 104

EP - 105

JO - Chinese Journal of Clinical Rehabilitation

JF - Chinese Journal of Clinical Rehabilitation

IS - 1

ER -

Mechanism of pathological changes in stroke: Role of PSD93 in neuron injury induced by platelet activating factor

Abstract

ASJC Scopus subject areas

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