Mechanism of global functional recovery despite sustained postischemic regional stunning

Willie E. Lawrence, William L Maughan, David A Kass

Research output: Contribution to journalArticle

Abstract

Background. The mechanisms whereby reperfusion of a 20-minute coronary occlusion result in global functional recovery despite persistent regional dysfunction were studied in 11 open-chest reflex-blocked dogs. Methods and Results. Pressure-volume and pressure-thickness relations were simultaneously determined before, during, and after reperfusion of left anterior descending artery (LAD) occlusion. Wall thickness was determined by sonomicrometry in both ischemic and remote regions. Chamber systolic function was assessed by end-systolic pressure-volume relations (ESPVR) obtained by conductance catheter and defined by a slope (Ees) and volume shift at a common end-systolic pressure (ΔVes). LAD occlusion produced regional systolic thinning (-7±6%) and global left ventricular dysfunction (ESPVR shifted rightward (ΔVes =+8.6±5.1 ml, p

Original languageEnglish (US)
Pages (from-to)816-827
Number of pages12
JournalCirculation
Volume85
Issue number2
StatePublished - Feb 1992

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Blood Pressure
Reperfusion
Arteries
Pressure
Coronary Occlusion
Left Ventricular Dysfunction
Reflex
Thorax
Catheters
Dogs

Keywords

  • Pressure-volume relation
  • Regional ischemia
  • Stunned myocardium
  • Ventricular function

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Mechanism of global functional recovery despite sustained postischemic regional stunning. / Lawrence, Willie E.; Maughan, William L; Kass, David A.

In: Circulation, Vol. 85, No. 2, 02.1992, p. 816-827.

Research output: Contribution to journalArticle

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